OPEN

Overcome failure to Publish nEgative fiNdings

Coordinatore	UNIVERSITAETSKLINIKUM FREIBURG    more  Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 contact info Nome: Jürgen Cognome: Dreyer Email: send email Telefono: +49 761 270 20810 Fax: +49 761 270 18890
Nazionalità Coordinatore	Germany [DE]
Totale costo	556˙629 €
EC contributo	499˙991 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-single-stage
Funding Scheme	CSA-SA
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2013-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAETSKLINIKUM FREIBURG  Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 contact info Nome: Jürgen Cognome: Dreyer Email: send email Telefono: +49 761 270 20810 Fax: +49 761 270 18890	DE (FREIBURG)	coordinator	101˙911.00
2	WORLD HEALTH ORGANIZATION.  Organization address address: Avenue Appia 20 city: GENEVE postcode: 1211 contact info Titolo: Dr. Nome: Davina Cognome: Ghersi Email: send email Telefono: 41227914401	CH (GENEVE)	participant	60˙936.00
3	FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU  Organization address address: CALLE SANT ANTONI M CLARET 167 city: BARCELONA postcode: 8025 contact info Titolo: Ms. Nome: Hilda Cognome: Herrero Email: send email Telefono: 34935537871 Fax: 34935537872	ES (BARCELONA)	participant	57˙929.00
4	EBERHARD KARLS UNIVERSITAET TUEBINGEN  Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 contact info Titolo: Dr. Nome: Dirk Cognome: Bassler Email: send email Telefono: 4970710000000	DE (TUEBINGEN)	participant	43˙763.00
5	ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI  Organization address address: Via Giuseppe La Masa 19 city: MILANO postcode: 20156 contact info Titolo: Dr. Nome: Silvano Cognome: Gallus Email: send email Telefono: 390239000000	IT (MILANO)	participant	36˙594.00
6	KLEIJNEN SYSTEMATIC REVIEWS LTD  Organization address address: RICCALL ROAD UNIT 6 city: ESCRICK YORK postcode: YO19 6FD contact info Titolo: Dr. Nome: Jos Cognome: Kleijnen Email: send email Telefono: 441905000000 Fax: 441905000000	UK (ESCRICK YORK)	participant	36˙594.00
7	GEMEINSAMER BUNDESAUSSCHUSS  Organization address address: WEGELYSTRASSE 8 city: BERLIN postcode: 10623 contact info Nome: Thomas Cognome: Gutekunst Email: send email Telefono: 4930280000000	DE (BERLIN)	participant	35˙898.00
8	MEDIZINISCHE HOCHSCHULE HANNOVER  Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 contact info Titolo: Prof. Nome: Daniel Cognome: Strech Email: send email Telefono: 495115000000	DE (HANNOVER)	participant	35˙898.00
9	UNIVERSITE PARIS DESCARTES  Organization address address: Rue de l'Ecole de Medecine 12 city: PARIS postcode: 75270 contact info Titolo: Prof. Nome: Philippe Cognome: Ravaud Email: send email Telefono: 33142348986	FR (PARIS)	participant	35˙203.00
10	ELIZABETH WAGER (SIDEVIEW)  Organization address address: STATION ROAD 19 city: PRINCES RISBOROUGH postcode: HP27 9DE contact info Titolo: Dr. Nome: Elizabeth Cognome: Wager Email: send email Telefono: 441844000000	UK (PRINCES RISBOROUGH)	participant	33˙919.00
11	SVEUCILISTE U SPLITU (UNIVERSITY OF SPLIT)  Organization address address: LIVANJSKA 5 city: SPLIT postcode: 21000 contact info Titolo: Prof. Nome: Ana Cognome: Marusic Email: send email Telefono: 38521557812	HR (SPLIT)	participant	21˙346.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Full information about completed and ongoing clinical trials is the indispensable base for decision making about medical therapies and diagnostic procedures by patients and doctors. Equally, researchers and research organisations, ethics boards, governments and health system agencies, courts for social justice, pharmaceutical companies and all professional groups of the health care system are dependent on unbiased information. Research projects have consistently shown that for approximately 50% of all launched trials results or reasons for their failure are never published. Not only pharmaceutical industry, but also researchers and their organisations, ethics boards and scientific journals are actively contributing to the general failure to come close to a 100% publication rate. An obvious reason is the complexity of the system as well as the limitation of resources, giving ample space for all stakeholders to avoid appropriate changes and draw attention to deficiencies outside their responsibility. This project is based on the assumption that the existence of broad publication bias with seriously harmful impact has been accepted by all stakeholders and does not require further evidence. The current knowledge on publication bias and its impact will be summarized by systematic reviews of the relevant literature, with emphasis on the situation in the EU. OPEN focuses on the investigation of attitudes and handling of stakeholders involved in the whole knowledge translation process. Surveys, case studies and analyses of policies to reduce publication bias will be conducted to describe the current views and practice of stakeholders who are involved in knowledge translation. These results will be brought together to describe the status quo. Based on those insights recommendations will be derived to reduce publication bias and thus foster the provision of relevant results from clinical trials to citizens and organisations in the EU.'

Introduzione (Teaser)

Publication bias, or dissemination bias, reflects a tendency on the part of researchers to submit and journals to publish, articles that have strong, positive findings. As a result, medical decision-making is based on a skewed evidence base.