THERMOREG

Peripheral and Central Mechanisms of Temperature Detection and Core Body Thermoregulation

Coordinatore	UNIVERSITAETSKLINIKUM HEIDELBERG    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙400˙725 €
EC contributo	1˙400˙725 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-02-01   -   2017-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT  Organization address address: ROBERT ROSSLE STRASSE 10 city: BERLIN postcode: 13125 contact info Titolo: Ms. Nome: Cornelia Cognome: Lanz Email: send email Telefono: 493094000000	DE (BERLIN)	beneficiary	413˙257.00
2	UNIVERSITAETSKLINIKUM HEIDELBERG  Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 contact info Titolo: Dr. Nome: Jan-Erik Cognome: Siemens Email: send email Telefono: +49 6221 548287 Fax: +49 6221 548589	DE (HEIDELBERG)	hostInstitution	987˙468.00
3	UNIVERSITAETSKLINIKUM HEIDELBERG  Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 contact info Titolo: Mr. Nome: Thorsten Cognome: Brietz Email: send email Telefono: +49 6221 567086 Fax: +49 6221 565460	DE (HEIDELBERG)	hostInstitution	987˙468.00

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 Obiettivo del progetto (Objective)

'Internal temperature homeostasis is of critical importance to our health as deviation from a normal, tightly controlled level (37 °Celsius) can cause fatal organ failures. Temperature-sensitive cells in the hypothalamus detect deep brain temperature, which is directly relevant to core body temperature (CBT) regulation. However molecules and mechanisms underlying central temperature detection by hypothalamic neurons are unknown. I propose to use a multi-disciplinary approach to elucidate mechanisms of temperature detection by these cells. I have started to employ a genetic tagging approach that allows me to label temperature-activated hypothalamic neurons in vivo. Hypothalamic neurons not only detect local brain temperature but also receive peripheral temperature signals from the somatosensory system. However, the impact of peripheral temperature information on central temperature regulation is largely unknown. Transient Receptor Potential (TRP) ion channels have been found to constitute important components in a variety of different sensory systems. In vertebrates, TRP family members TRPV1, TRPM8, and TRPA1, play prominent roles in the detection of thermal stimuli ranging from cold to hot ambient temperatures. How these receptors mediate their temperature sensitivity on the molecular level is largely unknown. I hypothesize that TRPs are components of supramolecular membrane-bound protein complexes that enable the receptors to function in a context-dependent manner, similar to the founding member of the TRP receptor family in the Drosophila eye. I will use a genetic biochemical strategy to identify components of somatosensory TRP channel protein complexes from native sensory ganglia of transgenic mice. Subsequently, characterization of the TRP Proteome will not only provide novel insights into TRP channel function as temperature sensors but may additionally yield novel targets for the treatment of inflammatory conditions and pain.'