INTERPREGGEN

Genetic studies of pre-eclampsia in Central Asian and European populations

Coordinatore	THE UNIVERSITY OF NOTTINGHAM    more  Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Ms. Nome: Alex Cognome: Hammond Email: send email Telefono: +44 115 8467896
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	7˙866˙606 €
EC contributo	5˙961˙648 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2011-single-stage
Funding Scheme	CP-FP-SICA
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-11-01   -   2016-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF NOTTINGHAM  Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD contact info Titolo: Ms. Nome: Alex Cognome: Hammond Email: send email Telefono: +44 115 8467896	UK (NOTTINGHAM)	coordinator	434˙441.00
2	GENOME RESEARCH LIMITED  Organization address address: THE GIBBS BUILDING, EUSTON ROAD 215 city: LONDON postcode: NW1 2BE contact info Titolo: Mr. Nome: David Cognome: Davison Email: send email Telefono: +44 1223 834244 Fax: +44 1223 494919	UK (LONDON)	participant	1˙963˙929.60
3	ISLENSK ERFDAGREINING EHF  Organization address address: Sturlugata 8 city: REYKJAVIK postcode: 101 contact info Titolo: Mr. Nome: Frosti Cognome: Jonsson Email: send email Telefono: +354 5701900	IS (REYKJAVIK)	participant	1˙424˙550.00
4	LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE  Organization address address: KEPPEL STREET city: LONDON postcode: WC1E7HT contact info Titolo: Mr. Nome: Greg Cognome: Dow Email: send email Telefono: +44 20 7927 2509	UK (LONDON)	participant	482˙450.00
5	"REPUBLICAN STATE ENTERPRISE WITH ECONOMIC MANAGEMENT SCIENTIFIC CENTRE OF OBSTETRICS, GYNECOLOGY AND PERINATOLOGY OF MINISTRY OF HEALTH"  Organization address address: DOSTYK AVE 125 city: ALMATY postcode: 50020 contact info Titolo: Prof. Nome: Gulnara Cognome: Svyatova Email: send email Telefono: 77273004562 Fax: 77273004561	KZ (ALMATY)	participant	400˙420.00
6	IMMUNOLOGIYA INSTITUTI O'ZBEKISTONRESPUBLIKASI FANLAR AKADEMIYASI  Organization address address: YA GULAMOV STREET 74 city: TASHKENT postcode: 100 contact info Titolo: Dr. Nome: Nodira Cognome: Zakhidova Email: send email Telefono: +99 897 7039800 Fax: +99 897 7039800	UZ (TASHKENT)	participant	300˙810.00
7	NASJONALT FOLKEHELSEINSTITUTT  Organization address address: Lovisenberggata 8 city: OSLO postcode: 403 contact info Titolo: Ms. Nome: Ane Cognome: Lunde Email: send email Telefono: +47 21078192 Fax: +47 22353606	NO (OSLO)	participant	280˙045.00
8	HELSINGIN YLIOPISTO  Organization address address: YLIOPISTONKATU 4 city: HELSINGIN YLIOPISTO postcode: 14 contact info Titolo: Ms. Nome: Tiina Cognome: Berg Email: send email Telefono: 358919000000	FI (HELSINGIN YLIOPISTO)	participant	209˙761.20
9	UNIVERSITY OF GLASGOW  Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Mr. Nome: Joe Cognome: Galloway Email: send email Telefono: +44 141 330 3884 Fax: +44 141 330 5611	UK (GLASGOW)	participant	172˙983.60
10	UNIVERSITY OF LEEDS  Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT contact info Titolo: Mr. Nome: Martin Cognome: Hamilton Email: send email Telefono: +44 113 343 4090 Fax: +44 113 343 4058	UK (LEEDS)	participant	114˙048.00
11	RESPUBLIKA ISTISOSLASHTIRILGAN AKUSHERLIK VA GINEKOLOGIYA ILMIY-AMALIY TIBBIYOT MARKAZI  Organization address address: MIRZO ULUGBEK 132-A city: Tashkent postcode: 100 contact info Titolo: Dr. Nome: Nodira Cognome: Zakhidova Email: send email Telefono: +99 897 7039800	UZ (Tashkent)	participant	107˙200.00
12	NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU  Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 contact info Titolo: Ms. Nome: Rannveig Cognome: Storeng Frøseth Email: send email Telefono: +47 72 573049 Fax: +47 72 571463	NO (TRONDHEIM)	participant	71˙010.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differences in genetic variants may be partly responsible for variation in predisposition to the condition. The AIMS of the InterPregGen consortium proposal are to establish sustainable and productive collaborative links between research groups in Central Asia (Kazakhstan and Uzbekistan) and Europe (Finland, Iceland, Norway, UK); and to identify and compare the genetic variants which predispose to pre-eclampsia. We shall achieve the first aim through scientific co-operation, and through training of Central Asian researchers in centres of excellence in Europe. We shall address the limited knowledge of genetic diversity in Central Asian populations by undertaking whole genome sequencing, analogous to the 1000 Genomes project. We will establish the first pre-eclampsia biobanks of DNA and plasma samples from a total of 4000 affected women, their partners and babies, and matched control samples from healthy pregnant women, in Kazakhstan and Uzbekistan. Existing genome-wide screening data, and data generated as part of this project, from a total of 10400 maternal cases and 7800 affected babies, will be used to identify pre-eclampsia susceptibility genes. We will maximise the information available by conducting meta-analyses of maternal and fetal datasets, and examining maternal-fetal gene interaction effects. By identifying genetic variants which predispose to pre-eclampsia we will gain insights into the underlying pathological mechanisms. This will generate novel hypotheses on the aetiology of pre-eclampsia, and provide targets for improved prediction, prevention and treatment'

Introduzione (Teaser)

An EU-funded project has designed the largest genetic study ever of women with pre-eclampsia, and their babies, in central Asia and Europe. Results are expected to deliver a predictive tool for the condition.