NEURALCODES_EMO

Deciphering neural codes of valence-based emotional memories

Coordinatore	WEIZMANN INSTITUTE OF SCIENCE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Israel [IL]
Totale costo	1˙671˙620 €
EC contributo	1˙671˙620 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-01-01   -   2016-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Dr. Nome: Ron Cognome: Paz Email: send email Telefono: 97289346236 Fax: 97289346162	IL (REHOVOT)	hostInstitution	1˙671˙620.00
2	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Gabi Cognome: Bernstein Email: send email Telefono: +972 8 934 6728 Fax: +972 8 934 4165	IL (REHOVOT)	hostInstitution	1˙671˙620.00

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 Obiettivo del progetto (Objective)

'Pioneering studies from the last decades have shown that we can use animal models to study the neural correlates of learning and emotional memories. These studies have identified a network of brain regions that co-orchestrate the dynamic processes that occur during acquisition, retrieval and update of memories with valence. In primates, these areas and their connectivity have evolved to allow a complex interaction between cognitive abilities and emotions. Although we know that emotional memories differ from neutral memories, the actual neural codes that underlie them are largely unknown. Understanding emotional memories at a detailed level in a primate model is a crucial step in our goal to understand ourselves, and would allow specific therapeutic interventions for a spectrum of psychiatric disorders. Our primary objectives are: a. to develop a comprehensive battery of behavioral paradigms that targets emotional learning and memory in non-human primates; b. to understand the neural mechanisms that underlie long-term evolvement of these memories; c. to develop a computational and experimental framework to understand coding in these high-dimensionality networks. We combine large-scale inter- and intra-regional simultaneous electrophysiological recordings in the primate amygdala and prefrontal-cortices, with a set of focused paradigms that use behavioral generalization as a tool to probe the underlying neural building blocks. Generalization is a highly-evolved cognitive ability of primates and a desired feature of any learning algorithm. Importantly, it is a tool to modify the brain and unveil the structure of its internal representations i.e. the neural code. Together, it will form a unified framework to understand neural codes of learning and memory formation in valence-based situations. Our research will help establishing an emerging field of computational affective neuroscience, and our vision holds that Emotion is finally within the reach of neurophysiology.'