QUANTERBIUM

"Quanterbium: Synthesis and photonic application of terbium–modified semiconductor quantum dots for highly sensitive, background-free, multiplexed biosensors"

Coordinatore	UNIVERSITE PARIS-SUD    more  Organization address address: RUE GEORGES CLEMENCEAU 15 city: ORSAY postcode: 91405 contact info Titolo: Mr. Nome: Nicolas Cognome: Lecompte Email: send email Telefono: +33 1 69155589
Nazionalità Coordinatore	France [FR]
Totale costo	194˙046 €
EC contributo	194˙046 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-IIF
Funding Scheme	MC-IIF
Anno di inizio	0
Periodo (anno-mese-giorno)	0000-00-00   -   0000-00-00

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE PARIS-SUD  Organization address address: RUE GEORGES CLEMENCEAU 15 city: ORSAY postcode: 91405 contact info Titolo: Mr. Nome: Nicolas Cognome: Lecompte Email: send email Telefono: +33 1 69155589	FR (ORSAY)	coordinator	194˙046.60

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 Obiettivo del progetto (Objective)

'In order to improve specificity, sensitivity and resolution of fluorescence-based diagnostic tools, Förster Resonance Energy Transfer (FRET) is a powerful technique. In our effort of developing new high sensitive FRET-based biosensors for multiplexing diagnostics, we propose preparation and applications of terbium-based quantum dots (Quanterbium Dots). The singular marriage between terbium complexes-donors (TCs) and quantum dots-acceptors (QDs) offers unprecedented performance and incredible versatility, thanks to the outstanding photophysical properties of the components and the easiness with which these properties can be selected and optimized for a facile tunability of the overall system. The Quanterbium project is based on the innovative idea of embedding TCs at variable positions inside a biocompatible polymeric QD coating; since the luminescence lifetime depends on the distance between the donor and the acceptor, FRET events would be controlled exclusively by the synthesis and the lifetime information could be efficiently used as a new multiplexing dimension. This novel approach will lead to the “universal nanoprobe” because both its luminescence color (QDs size) and lifetime (TC-QD distance) can be tuned at will during the synthetic process. This project will be a giant leap forward toward the development of super sensitive biosensors, because FRET will be implemented within the chemical system itself, regulated only by the voluntary and controlled preparation of the components, and completely independent from any 'external' biological process. The main objectives of the project are the synthesis and the characterization of biocompatible Quanterbium Dots, the evaluation of their performance concerning multiplexing abilities and sensitivity for optical spectroscopy and imaging, and their application for biological sensing. Herein, we propose a detailed description of the strategy and the methodology for the successful achievement of the objectives.'