VIRAFRONT

Viral frontiers – species barriers of hepatitis C virus replication

Coordinatore	"TWINCORE, ZENTRUM FUR EXPERIMENTELLE UND KLINISCHE INFEKTIONSFORSCHUNG GMBH"    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙444˙515 €
EC contributo	1˙444˙515 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2011-StG_20101109
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-02-01   -   2017-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	"TWINCORE, ZENTRUM FUR EXPERIMENTELLE UND KLINISCHE INFEKTIONSFORSCHUNG GMBH"  Organization address address: FEODOR LYNEN STRASSE 7 city: Hannover postcode: 30625 contact info Titolo: Prof. Nome: Thomas Cognome: Pietschmann Email: send email Telefono: +49 511 220027130 Fax: +49 511 220027139	DE (Hannover)	hostInstitution	1˙444˙515.59
2	"TWINCORE, ZENTRUM FUR EXPERIMENTELLE UND KLINISCHE INFEKTIONSFORSCHUNG GMBH"  Organization address address: FEODOR LYNEN STRASSE 7 city: Hannover postcode: 30625 contact info Titolo: Prof. Nome: Ulrich Cognome: Kalinke Email: send email Telefono: +49 511 220027112 Fax: +49 511 220027186	DE (Hannover)	hostInstitution	1˙444˙515.59

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 Obiettivo del progetto (Objective)

'RNA viruses are responsible for important acute, chronic as well as emerging human infections. While some of these viruses – like for instance the hepatitis C virus (HCV) – are highly species-specific, others (e.g. Dengue Virus) infect different host species. These latter viruses cause zoonotic infections, i.e. infections of animal hosts that are transmitted to humans by unintentional contact. Why some RNA viruses are highly species-specific, whereas others have a broad species-tropism is poorly understood. Moreover, host-derived control mechanisms that prevent viruses to transmit across species barriers and viral evasion and adaptation strategies are only beginning to emerge. While climatic changes, augmented population density and mobility increase the risk for human exposure to novel RNA viruses, therapeutics preventing disease in humans or precluding transmission are lacking. In some cases, small animal models for drug discovery, vaccine research and pathogenesis studies are not available. The objective of the proposal is to define all factors that prevent HCV propagation in mouse liver cells. The inability of HCV to propagate in non-human cells may be due to lack or genetic incompatibility of essential viral replication co-factors and/or due to antiviral restriction mechanisms effectively suppressing viral replication in non-human host cells. Taking this into account, both rationale and unbiased genetic screening systems will be employed to derive a comprehensive profile of all factors relevant to the species barrier for HCV infection of mouse cells. Moreover, viral adaptation and evasion strategies to overcome these barriers will be explored. These pioneer studies will prepare the ground for development of urgently needed HCV small animal models and provide valuable insights into the mechanisms of pathogen control at species barriers. This should promote future development of strategies which prevent zoonotic transmission of emerging RNA viruses to humans.'