ENDETECH

ENzymatic DEcontamination TECHnology

Coordinatore	DA VOLTERRA SAS    more  Organization address address: RUE DE CHARONNE 172 city: PARIS postcode: 75011 contact info Titolo: Ms. Nome: Florence Cognome: Sejourne Email: send email Telefono: +33 1 58 39 32 20 Fax: +33 1 58 39 32 21
Nazionalità Coordinatore	France [FR]
Totale costo	2˙558˙330 €
EC contributo	1˙994˙648 €
Programma	FP7-ENVIRONMENT Specific Programme "Cooperation": Environment (including Climate Change)
Code Call	FP7-ENV-2011-ECO-INNOVATION-TwoStage
Funding Scheme	CP
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-02-01   -   2015-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	DA VOLTERRA SAS  Organization address address: RUE DE CHARONNE 172 city: PARIS postcode: 75011 contact info Titolo: Ms. Nome: Florence Cognome: Sejourne Email: send email Telefono: +33 1 58 39 32 20 Fax: +33 1 58 39 32 21	FR (PARIS)	coordinator	450˙888.50
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE  Organization address address: Rue Michel -Ange 3 city: PARIS postcode: 75794 contact info Titolo: Dr. Nome: Jocelyn Cognome: Mere Email: send email Telefono: +33 4 67613535 Fax: +33 4 67043236	FR (PARIS)	participant	511˙240.40
3	C-LECTA GMBH  Organization address address: Deutscher Platz 5b city: Leipzig postcode: 4103 contact info Titolo: Dr. Nome: Stefan Cognome: Schönert Email: send email Telefono: +49 341 35521426	DE (Leipzig)	participant	291˙204.60
4	CHIRALVISION BV  Organization address address: J.H. Oortweg 21 city: LEIDEN postcode: 2333 CH contact info Titolo: Dr. Nome: Rob Cognome: Schoevaart Email: send email Telefono: +31 713322124 Fax: +31 713322125	NL (LEIDEN)	participant	289˙406.50
5	JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT AM MAIN  Organization address address: GRUNEBURGPLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 contact info Titolo: Prof. Nome: Jörg Cognome: Oehlmann Email: send email Telefono: +49 69 798 42142 Fax: +49 69 798 42141	DE (FRANKFURT AM MAIN)	participant	233˙070.00
6	Nome Ente NON disponibile  Organization address address: CALLE PIC DE PEGUERA 15 city: Girona postcode: 17004 contact info Titolo: Dr. Nome: Jaume Cognome: Alemany Email: send email Telefono: +34 972 183 455 Fax: +34 972 183 248	ES (Girona)	participant	218˙838.00

Mappa

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 Obiettivo del progetto (Objective)

'Human activities are associated with increasing amounts of waste that ultimately find their ways into European waters and have negative consequences on the environment. With the background of an aging population and increasing urbanization, wastewater treatment must specifically target pharmaceutical products (PPs) and endocrine disrupting chemicals (EDCs) so that these highly biologically-active compounds are eliminated from the water resource.

If conventional treatment technologies are very efficient on a large number of compounds, some chemicals, such as pharmaceutical residues and endocrine disruptors, are recalcitrant and are not removed. The chronic exposure to these compounds is a topic of threat as the long term effects are so far unpredictable and undocumented. This issue has recently drawn the interest of many medical professionals, eco-toxicologists and environmental and health agencies. The global objective of the ENDETECH program is to develop a technology which aims at eliminating persistent pharmaceutical pollutants in wastewaters originating from drug manufacturing sites, households, hospitals and animal farms, thanks to an innovative ENzymatic DEcontamination TECHnology.

The pharmaceutical pollutants targeted in priority during this project will be antibiotics, hormones and endocrine disruptors.

The ENDETECH program is articulated around three main steps: (1) enzyme libraries will be screened to identify novel enzymes able to inactivate the selected pollutants; (2) the discovered enzymes will be immobilized on beads or membranes and subsequently (3) used in bioreactors to decontaminate waste effluents.

The ENDETECH consortium includes all the needed and complementary skills for the project in the fields of enzyme screening, optimization and immobilization, bioreactor development & design and chemical & eco-toxicological analysis. The ENDETECH network is composed of 3 SMEs and 3 RTD organizations.'

Introduzione (Teaser)

Cleaning pharmaceutical waste from water

Descrizione progetto (Article)

Certain pharmaceutical compounds are not easily removed from wastewater, and these can have long-term health effects in exposed populations. With an ageing population and increased urbanisation, it is important that the presence of these pollutants in the water supply is addressed.

In response, the EU-funded 'Enzymatic decontamination technology' (http://endetech.eu (ENDETECH)) project aims to develop an enzyme-based decontamination system. It targets antibiotics, hormones, endocrine disruptors and other common drugs.

Researchers began by investigating the eco-toxicity of the target compounds, as well as any potential breakdown products. Next, they developed several tests for enzyme activity against antibiotics, hormones and carbamazepine (a common psychiatric drug).

Enzyme libraries are being screened to identify enzymes that will digest these pollutants. So far, several laccase enzymes and an esterase enzyme have shown activity against some or all of the compounds.

ENDETECH has also started the design of an enzyme reactor system. A literature review of closed reactor design has been completed, and work has started on immobilising enzymes on beads or membranes for use in the reactor.

Future work of the ENDETECH project will focus on finalising and scaling up the enzyme reactor system. Once complete, the project is set to contribute to water quality both in the EU and globally.