UB-DECODED
Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity
| Coordinatore | UNIVERSITY COLLEGE LONDON
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 2˙367˙337 € |
| EC contributo | 2˙367˙337 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2011-ADG_20110310 |
| Funding Scheme | ERC-AG |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-04-01 - 2017-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | beneficiary | 627˙725.10 |
| 2 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | hostInstitution | 1˙739˙611.90 |
| 3 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | hostInstitution | 1˙739˙611.90 |
Mappa
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Obiettivo del progetto (Objective)
'Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer. Signalling processes mediated by ubiquitin are crucial for TNF signalling. The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin chains. Employing a method newly developed in our laboratory we identified the presence of four of these ubiquitin chain linkage types in the native TNF receptor signalling complex (TNF-RSC). Our knowledge of the specific functions of the different ubiquitin linkages is currently very limited. However, their presence in the TNF-RSC, combined with our recent technological advance in dissecting the composition of this protein complex with previously unreached specificity and sensitivity provides a unique opportunity for the proposed research programme: to molecularly and functionally decipher the ubiquitin code. We will aim to achieve this by studying the different ubiquitin chain linkages at the molecular level within the TNF-RSC and by determining how perturbation of specific ubiquitin linkage events impacts the physiological role of TNF in immunity to infection and its pathological function in inflammation-induced cancer. The specific objectives of this project are: • to molecularly decipher the ubiquitin code of the TNF-RSC (objective 1), • to link this code to physiological functions of TNF in immunity to infection (objective 2) • and to test its pathological impact on cancer-related inflammation (objective 3).'