VISTO

Visualizing tolerance induction: behavior and function of regulatory T cells during the establishment of materno/fetal tolerance

 Coordinatore UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 

 Organization address address: Place Jussieu 4
city: PARIS
postcode: 75252

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Wiest
Email: send email
Telefono: +33 1 44 27 97 58
Fax: +33 1 44 27 23 00

 Nazionalità Coordinatore France [FR]
 Totale costo 201˙932 €
 EC contributo 201˙932 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-03-01   -   2014-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6

 Organization address address: Place Jussieu 4
city: PARIS
postcode: 75252

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Wiest
Email: send email
Telefono: +33 1 44 27 97 58
Fax: +33 1 44 27 23 00

FR (PARIS) coordinator 201˙932.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

mouse    therapeutic    immune    transplantation    implications    spontaneous    autoimmune    diseases    similarities    escape    regulatory    materno    mechanisms    abortion    cells    tissue    tumor    organ    tolerance    fetal    pregnancy   

 Obiettivo del progetto (Objective)

'The presence of foreign (allogenic) tissue in a host yields an immune response with the goal to destroy the tissue. During pregnancy, however, the semiallogenic fetus is allowed to grow within the maternal uterus. This ‘immunological paradox of pregnancy’ has received much attention because of its therapeutic implications in organ transplantation and autoimmune diseases.While it has recently been established that regulatory T cells are essential in establishing tolerogenic conditions during pregnancy, little is known about where and when T regulatory act. I will characterize, using transgenic mouse lines and intra-vital two photon microscopy, the spatio-temporal characteristics of T regulatory cell recruitment at the materno/fetal interface. I will analyze the dynamics of cellular interactions between T regulatory cells with other immune system cells under physiological conditions and in a mouse model of spontaneous abortion. Finally, I will use a candidate gene approach to reveal similarities between molecular mechanisms of materno/fetal tolerance and tumor immune escape. A better understanding of the mechanisms leading to materno/fetal tolerance will have therapeutic implications for the treatment of patients with recurrent spontaneous abortion and pre-eclampsia, for organ transplantation and for autoimmune diseases. Moreover, the interdisciplinary comparison of similarities between materno/fetal tolerance and tumor immune escape will provide novel experimental approaches for tumor immuno-therapy.'

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