CGDM

Cancer Gene Discovery Using Somatic Gene Transfer in Mice

Coordinatore	MAGYAR TUDOMANYOS AKADEMIA SZEGEDI BIOLOGIAI KOZPONTJA    more  Organization address address: Temesvari krt. 62 city: SZEGED postcode: 6701 contact info Titolo: Dr. Nome: Peter Cognome: Heffner Email: send email Telefono: 3662599727
Nazionalità Coordinatore	Hungary [HU]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2011-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-04-01   -   2016-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAGYAR TUDOMANYOS AKADEMIA SZEGEDI BIOLOGIAI KOZPONTJA  Organization address address: Temesvari krt. 62 city: SZEGED postcode: 6701 contact info Titolo: Dr. Nome: Peter Cognome: Heffner Email: send email Telefono: 3662599727	HU (SZEGED)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Cancer is the leading cause of death in the developed world. Significant emphasis has recently been placed on the characterization of the human cancer genome. However, the genetic complexity of cancer has complicated the identification of driver mutations among the more abundant passenger mutations found in tumours. Forward genetic screens are powerful methods to identify genes involved in specific biological processes like cancer formation. However the difficulties and costs currently associated to such screens in vivo in mammalian systems are equally enormous. Here I propose the creation of a novel site-directed gene transfer system, allowing efficient and controlled somatic gene transfer in vivo in mice. This approach offers the possibility for the rapid creation of large number of somatic clones, over-expressing target proteins, or carrying transgenes to trigger RNAi response against the targeted gene products. I plan to screen cancer related miR-based gene knockdown libraries in this system, for the identification of novel genes involved in suppressing tumour formation. Recent findings are emphasizing the role of genomic instability caused by errors of DNA repair in the development of cancer. Using candidate gene approach I would like to investigate such mechanisms by the help of the proposed in vivo test system.'