FISHIL10
Host and viral Interleukin-10 in fish: evolution of a regulatory cytokine
| Coordinatore | WAGENINGEN UNIVERSITY
Organization address
address: DROEVENDAALSESTEEG 4 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 183˙805 € |
| EC contributo | 183˙805 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2011-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-05-01 - 2014-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
WAGENINGEN UNIVERSITY
Organization address
address: DROEVENDAALSESTEEG 4 contact info |
NL (WAGENINGEN) | coordinator | 183˙805.80 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Interleukin (IL)-10 is a cytokine that, at least in mammals, plays a central role in innate and adaptive immunity. IL-10 limits inflammation by acting on macrophages and promotes anti-inflammatory responses via T-helper cells. Underlining the regulatory role of IL-10 is the presence of IL-10 homologues in viral genomes (vIL-10). IL-10 has been cloned in several fish species but only recently a vIL-10 has been identified in the genome of koi-herpes-virus (KHV), a highly pathogenic virus of carp. Very little is known about the function of fish IL-10 and nothing is known about the activity of khvIL-10. However, the presence of this cytokine in both fish and their viruses, suggests a conservation of function throughout the vertebrate lineage. The first aim is to identify IL-10-producing leukocytes in carp. The second aim is to study the effect(s) of carp and KHV IL-10 on different leukocytes, in vitro. The third aim is to investigate the immunomodulatory effect(s) of carp and KHV IL-10 in vivo during a natural infection of carp. The overall aim is to investigate the biological activity of both host and viral IL-10 in fish to study the evolutionary conservation of function of this important regulatory cytokine.'