BRASINOEU
Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles
| Coordinatore | UNIVERSITAET LEIPZIG
Organization address
address: RITTERSTRASSE 26 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 428˙400 € |
| EC contributo | 428˙400 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2012-IRSES |
| Funding Scheme | MC-IRSES |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-01-01 - 2016-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAET LEIPZIG
Organization address
address: RITTERSTRASSE 26 contact info |
DE (LEIPZIG) | coordinator | 98˙700.00 |
| 2 |
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES
Organization address
address: PASEO MIRAMON PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C 182 contact info |
ES (SAN SEBASTIAN) | participant | 199˙500.00 |
| 3 |
TYOETERVEYSLAITOS
Organization address
address: Topeliuksenkatu 41 a A contact info |
FI (HELSINKI) | participant | 65˙100.00 |
| 4 |
INSTYTUT FIZYKI POLSKIEJ AKADEMII NAUK
Organization address
address: AL LOTNIKOW 32/46 contact info |
PL (WARSZAWA) | participant | 33˙600.00 |
| 5 |
WARSZAWSKI UNIWERSYTET MEDYCZNY
Organization address
address: UL. ZWIRKI I WIGURY 61 contact info |
PL (WARSZAWA) | participant | 31˙500.00 |
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Obiettivo del progetto (Objective)
'BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by design” is based on the application of nanosafety to design the nanomaterials in order to prevent or reduce their possible harm to humans and the environment. The project encompass the synthesis of metal oxide NPs, with a focus on magnetic oxides, their surface modification and post modification in biological fluids; immunological and genotoxicity studies, and translocation studies both “in vitro” and “in vivo”. The project will seek to establish relationships between designed NP properties and their translocation at cellular and body level as well as their immune- and genotoxic response. This is a fundamental issue for the safe design of NPs. Also, the toxicological response will be studied as a function of the uptake dose of NPs. At cellular level a battery of techniques will be applied for localization and quantification of NPs: Transmission Electron Microscopy, Raman, Confocal Microscopy, Ion Beam Microscopy, etc. Positron Emission Tomography and Magnetic Resonance Imaging will be employed for biodistribution and quantification studies in animal models. BRASINOU is formed by an international team with the required and complementary expertise to address the proposed work from an international and multidisciplinary perspective. The project gathers internationally recognized groups in immunology, genotoxicity, nanoparticle synthesis, surface chemistry, biophysics, imaging and materials science. The complementary of the groups involved in the project will help to develop new highly skilled professional and scientific horizontal connections.'