SLEEPNEED

Cortical neuronal mechanisms of behavioural and cognitive deficits after sleep deprivation

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD    more  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-09-01   -   2016-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD  Organization address address: University Offices, Wellington Square city: OXFORD postcode: OX1 2JD contact info Titolo: Ms. Nome: Gill Cognome: Wells Email: send email Telefono: +44 1865 289800 Fax: +44 1865 289801	UK (OXFORD)	coordinator	68˙750.00
2	UNIVERSITY OF SURREY  Organization address address: Stag Hill city: GUILDFORD postcode: GU2 7XH contact info Titolo: Ms. Nome: Maria Cognome: Sega-Buhalis Email: send email Telefono: +44 1483 683498 Fax: +44 1483 683791	UK (GUILDFORD)	participant	31˙250.00

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 Obiettivo del progetto (Objective)

'A significant portion of our life is spent asleep and we still do not know why. Chronic sleep deprivation and sleep disorders are experienced by millions of people in our society, and sleep loss has profound effects on brain activity and cognitive functions. Surprisingly, we still do not know what happens in the brain after sleep deprivation that makes us feel tired and impaired even in simple tasks. The objective of this project is to provide an understanding of neuronal mechanisms underlying behavioural, sensory and cognitive changes incurred after sleep deprivation, through a suite of state-of-the-art neurophysiological techniques and methodologies. We hypothesize that prior waking experience results in specific changes in the activity of cortical neuronal networks that in turn directly results in an impaired cognition and necessitates sleep. In order to address this hypothesis we will use visual stimulation, sensory gating and ‘oddball’ paradigms, spatial navigation and reaction time tasks in rats and mice in vivo. Furthermore, we will exploit conventional and conditional knock-out mouse models to investigate global and local effects of metabotropic glutamate and GABA receptors on wake- and experience-dependent changes in cortical neuronal activity during sleep deprivation. This work will not only help to explain specific mechanisms underlying behavioural and sensory deficits after sleep deprivation, but by doing so will pave the way towards more focused innovative research relevant for public health and safety.'