MU TUNING

Fine Tuning the Final Common Pathway: Molecular Determinants of Motor Unit Development and Plasticity

 Coordinatore UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS 

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 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙456˙807 €
 EC contributo 1˙456˙807 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2012-StG_20111109
 Funding Scheme ERC-SG
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-11-01   -   2017-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

 Organization address address: Robert-Koch-Strasse 40
city: GOETTINGEN
postcode: 37075

contact info
Titolo: Dr.
Nome: Till
Cognome: Marquardt
Email: send email
Telefono: 495514000000
Fax: 49551399843

DE (GOETTINGEN) hostInstitution 1˙456˙807.00
2    UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS

 Organization address address: Robert-Koch-Strasse 40
city: GOETTINGEN
postcode: 37075

contact info
Titolo: Ms.
Nome: Christiane
Cognome: Hennecke
Email: send email
Telefono: +49 551 39 8770
Fax: +49 551 39 22593

DE (GOETTINGEN) hostInstitution 1˙456˙807.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

chick    pathways    vulnerability    motor    electrophysiological    contribution    mouse    muscle    output    mns    pathway    determining    components    newly    candidate    fiber    neuromuscular    types    mn    function    plasticity    specification    molecular   

 Obiettivo del progetto (Objective)

'Motor neurons (MNs) constitute the final common pathway in the generation of behaviors by linking the CNS with the movement apparatus. Herein, MNs diversify into fast, intermediate and slow types whose properties are tuned to the speed, force and endurance of the muscle fiber contractions they elicit. The MN-muscle fiber units display marked plasticity towards chronically altered physical activity, and show strong differences in their vulnerability towards degenerative conditions affecting the neuromuscular system, including amyotrophic lateral sclerosis and aging. Despite their central importance for determining neuromuscular output, plasticity and vulnerability the molecular mechanisms determining the functional MN types remain unknown. My group will use a cross-disciplinary approach by employing molecular genetic, cell biological, electrophysiological and motor behavior assays in mouse and chick to dissect molecular pathways determining MN type status and their contribution to neuromuscular system function and plasticity. Based on our preliminary data, this will focus on the contribution of non-canonical Notch signaling to MN type-specification and neuromuscular function, in addition to four newly identified neural activity modulators as candidate effectors of motor unit output and plasticity. This will be complemented by screening additional pathway components for roles in determining MN type properties through newly developed rapid gene tagging and electrophysiological interrogation in chick, followed by addressing their requirement for motor unit specification and function in mouse. Through an iterative cycle of (i) investigating candidate determinants of motor unit type, (ii) defining their role and mode of action in motor unit specification and function in the context of the neuromuscular system, and (iii) identifying essential downstream components, the proposal will explore molecular pathways operating in motor unit specification, function and plasticity.'

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