MU TUNING

Fine Tuning the Final Common Pathway: Molecular Determinants of Motor Unit Development and Plasticity

Coordinatore	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙456˙807 €
EC contributo	1˙456˙807 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111109
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-11-01   -   2017-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS  Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 contact info Titolo: Dr. Nome: Till Cognome: Marquardt Email: send email Telefono: 495514000000 Fax: 49551399843	DE (GOETTINGEN)	hostInstitution	1˙456˙807.00
2	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS  Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 contact info Titolo: Ms. Nome: Christiane Cognome: Hennecke Email: send email Telefono: +49 551 39 8770 Fax: +49 551 39 22593	DE (GOETTINGEN)	hostInstitution	1˙456˙807.00

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 Obiettivo del progetto (Objective)

'Motor neurons (MNs) constitute the final common pathway in the generation of behaviors by linking the CNS with the movement apparatus. Herein, MNs diversify into fast, intermediate and slow types whose properties are tuned to the speed, force and endurance of the muscle fiber contractions they elicit. The MN-muscle fiber units display marked plasticity towards chronically altered physical activity, and show strong differences in their vulnerability towards degenerative conditions affecting the neuromuscular system, including amyotrophic lateral sclerosis and aging. Despite their central importance for determining neuromuscular output, plasticity and vulnerability the molecular mechanisms determining the functional MN types remain unknown. My group will use a cross-disciplinary approach by employing molecular genetic, cell biological, electrophysiological and motor behavior assays in mouse and chick to dissect molecular pathways determining MN type status and their contribution to neuromuscular system function and plasticity. Based on our preliminary data, this will focus on the contribution of non-canonical Notch signaling to MN type-specification and neuromuscular function, in addition to four newly identified neural activity modulators as candidate effectors of motor unit output and plasticity. This will be complemented by screening additional pathway components for roles in determining MN type properties through newly developed rapid gene tagging and electrophysiological interrogation in chick, followed by addressing their requirement for motor unit specification and function in mouse. Through an iterative cycle of (i) investigating candidate determinants of motor unit type, (ii) defining their role and mode of action in motor unit specification and function in the context of the neuromuscular system, and (iii) identifying essential downstream components, the proposal will explore molecular pathways operating in motor unit specification, function and plasticity.'