S-RNA-S

Small ribonucleic acids in silico

Coordinatore	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Italy [IT]
Totale costo	1˙295˙700 €
EC contributo	1˙295˙700 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111012
Funding Scheme	ERC-SG
Anno di inizio	2012
Periodo (anno-mese-giorno)	2012-10-01   -   2017-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI  Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Dr. Nome: Giovanni Cognome: Bussi Email: send email Telefono: 390404000000 Fax: 390404000000	IT (TRIESTE)	hostInstitution	1˙295˙700.00
2	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI  Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Mr. Nome: Gabriele Cognome: Rizzetto Email: send email Telefono: +39 040 3787201 Fax: +39 040 3787249	IT (TRIESTE)	hostInstitution	1˙295˙700.00

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 Obiettivo del progetto (Objective)

'Ribonucleic acid (RNA) is acquiring a larger importance in cell biology, as more functions that it accomplishes are discovered. In particular, as it has emerged in the last decade, it has a crucial role in the post-transcriptional regulation of gene expression. The comprehension of these mechanisms and, in general, of RNA properties at a molecular level is a key issue in the study of many diseases and paves the way to possible applications in molecular medicine. Particularly interesting in this context are riboswitches, small portions of messenger RNAs which change their conformation in presence of specific metabolites and consequently inhibit or enhance gene transcription or translation. Another issue of paramount interest is RNA metabolism, crucial for viral replication, and in particular of the interaction of RNAs and the molecular motors devoted to its manipulation and unwinding. One of the goals of the present project is to develop new in silico approaches based on molecular dynamics for the study of small RNA molecules. In particular, the research will focus on (a) the development of ad hoc techniques to accelerate molecular dynamics simulations of RNA and of RNA-protein complexes and (b) to predict the three-dimensional structure of small RNAs. Another major goal of the present project is to apply the aforementioned techniques, in combination with standard molecular dynamics and state-of-the-art rare-event methods, to the study of three extremely relevant topics: (a) the interaction between RNA and the helicases, which are the enzymes devoted to its unwinding in the cell, (b) the conformational transitions in riboswitches, and (c) the structure of non-coding inverted short interspersed elements (SINE).'