SUMOSTRESS
"Integrating the activities of SUMO in gene expression, inflammation and cancer"
| Coordinatore | INSTITUT PASTEUR
Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie. |
| Nazionalità Coordinatore | France [FR] |
| Totale costo | 2˙499˙996 € |
| EC contributo | 2˙499˙996 € |
| Programma | FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | ERC-2011-ADG_20110310 |
| Funding Scheme | ERC-AG |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-04-01 - 2018-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | hostInstitution | 2˙499˙996.00 |
| 2 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | hostInstitution | 2˙499˙996.00 |
Mappa
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Obiettivo del progetto (Objective)
'Sumoylation of proteins has emerged as a central regulatory mechanism influencing a wide range of cellular processes and is notably a key pathway facilitating cellular response to stress. Gene expression appears to be particularly regulated by sumoylation as many known SUMO substrates are transcription factors and cofactors. Moreover, key chromatin proteins, including the core histones, figure among the SUMO targets. The emerging paradigm for the proposed work is that sumoylation controls multiple aspects of chromatin structure and that sumoylated proteins are principal and instructive components of a dynamic chromatin scaffold that can respond to external cues. According to this view, sumoylation is expected to impact both global and specific transcriptional programs thereby affecting constitutive and inducible gene expression. The goal of this project is to define the role of sumoylation-mediated gene control in stress response and to analyze the impact of dysregulation of this pathway in inflammation and cancer with a primary focus on the intestinal tract. Our specific aims are to 1) Identify stress-regulated molecular players of the SUMO pathway, 2) Define the genome-wide organization of the SUMO chromatin landscape and its plasticity upon stress, 3) Probe the role of sumoylation in normal and pathological inflammatory response with an emphasis on acute and chronic colitis, 4) Explore the possible implication of the SUMO pathway in colon cancer. This project is supported by a wealth of preliminary data based on genomic approaches and mouse models for partial or complete loss of sumoylation. We expect our study to bring innovative concepts on sumoylation’s role in normal and disease states. Novel regulators of sumoylation will be identified, unsuspected transcriptional networks will be uncovered, determinants of human malignancies and inflammatory diseases will potentially be identified, with a view toward therapeutic strategies seeking to manipulate sumoylation.'