INSERT

Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy

Coordinatore	POLITECNICO DI MILANO    more  Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 contact info Titolo: Mr. Nome: Fabio Cognome: Conti Email: send email Telefono: +39 02 2399 3431 Fax: +39 02 2399 3417
Nazionalità Coordinatore	Italy [IT]
Totale costo	5˙981˙463 €
EC contributo	4˙600˙000 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-03-01   -   2017-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	POLITECNICO DI MILANO  Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 contact info Titolo: Mr. Nome: Fabio Cognome: Conti Email: send email Telefono: +39 02 2399 3431 Fax: +39 02 2399 3417	IT (MILANO)	coordinator	715˙000.00
2	Mediso Orvosi Berendezes Fejleszto es Szerviz Kft.  Organization address address: ALSOTOROKVESZ 14 city: BUDAPEST postcode: 1022 contact info Titolo: Ms. Nome: Erzsébet Cognome: Zelei Email: send email Telefono: +36 13993030 Fax: +36 13993040	HU (BUDAPEST)	participant	1˙100˙000.00
3	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mrs. Nome: Greta Cognome: Borg-Carbott Email: send email Telefono: +44 2031083033 Fax: +44 2078132849	UK (LONDON)	participant	700˙000.00
4	MRI. TOOLS GMBH  Organization address address: ROBERT ROSSLE STRASSE 10 city: BERLIN postcode: 13125 contact info Titolo: Prof. Nome: Thoralf Cognome: Niendorf Email: send email Telefono: +49 30 9406 4513 Fax: +49 30 9406 49178	DE (BERLIN)	participant	500˙000.00
5	FONDAZIONE BRUNO KESSLER  Organization address address: VIA SANTA CROCE 77 city: TRENTO postcode: 38122 contact info Titolo: Mr. Nome: Umberto Cognome: Silvestri Email: send email Telefono: +39 0461 314375 Fax: +39 0461302040	IT (TRENTO)	participant	400˙000.00
6	CROMED KUTATO ES SZOLGALTATO KOZPONTOK KFT  Organization address address: BAROSS UTCA 91 95 city: BUDAPEST postcode: 1047 contact info Titolo: Mr. Nome: Péter Cognome: Riczu Email: send email Telefono: +36 14591500 Fax: +36 12666656	HU (BUDAPEST)	participant	350˙000.00
7	UNIVERSITA DEGLI STUDI DI MILANO  Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 contact info Titolo: Dr. Nome: Maria Antonia Cognome: Giofrè Email: send email Telefono: +39 02 50320435 Fax: +39 02 50320448	IT (MILANO)	participant	270˙000.00
8	UNIVERSITA VITA-SALUTE SAN RAFFAELE  Organization address address: Via Olgettina 58 city: MILANO postcode: 20132 contact info Titolo: Dr. Nome: Maria Rosa Cognome: Pedrazzi Email: send email Telefono: +39 02 2643 4845	IT (MILANO)	participant	250˙000.00
9	NUCLEARFIELDS INTERNATIONAL BV  Organization address address: AKKERVOORTWEG 7-11 city: VORTUM MULLEM postcode: 5827AP contact info Titolo: Mr. Nome: Gerjan Cognome: Roelofs Email: send email Telefono: +31 485561111	NL (VORTUM MULLEM)	participant	200˙000.00
10	CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL  Organization address address: Via Giuseppe Mussi 1 city: MILANO postcode: 20154 contact info Titolo: Ms. Nome: Carla Cognome: Finocchiaro Email: send email Telefono: +39 02 3108331	IT (MILANO)	participant	115˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'The purpose of the project INSERT is to provide clinically relevant stratification and improved personalized radio-chemo therapy for brain tumour patients using a specifically developed multi-modality imaging tool. The system will also be used for early assessment of treatment efficacy. The initial focus will be on patients with glioma but there is future potential to target a range of tumours in the head and neck region. The proposed system is based on the development of a novel SPECT (Single Photon Emission Computed Tomography) system, suitable for insertion in the bore of an existing MRI (Magnetic Resonance Imaging) system, a cost-effective solution for widespread application. The combined system will allow the simultaneous measurement of anatomical (MRI) and functional (SPECT & MRI) information and the evaluation of their correlation in space and time. The SPECT design will enable acquisition of fast dynamic studies, with possibility for simultaneous measurement using multiple radionuclides (emitting at different energies), a distinct advantage compared to positron emission tomography (PET). This property can allow in-vivo simultaneous visualisation of spectrally resolved molecular and biochemical tumour properties. The stationary SPECT system is based on recently developed innovative gamma-ray detectors made with Silicon Drift Photodetectors, technology that achieves high-spatial resolution and is compatible with MRI thanks to the use of a silicon photodetector instead of photomultiplier tubes. The multi-modality SPECT/MRI imaging here proposed will apply a fully translational, vertical integration of research and development from technology design through preclinical models to clinical validation.'

Introduzione (Teaser)

Cancer diagnosis and progression monitoring present significant medical challenges. Advanced, non-invasive imaging methods are therefore needed to monitor the outcome of cancer treatment.