INSERT
Development of an integrated SPECT/MRI system for enhanced stratification of brain tumour patients prior to patient-specific radio-chemo therapy and early assessment of treatment efficacy
| Coordinatore | POLITECNICO DI MILANO
Organization address
address: PIAZZA LEONARDO DA VINCI 32 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Totale costo | 5˙981˙463 € |
| EC contributo | 4˙600˙000 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2012-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-03-01 - 2017-02-28 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
POLITECNICO DI MILANO
Organization address
address: PIAZZA LEONARDO DA VINCI 32 contact info |
IT (MILANO) | coordinator | 715˙000.00 |
| 2 |
Mediso Orvosi Berendezes Fejleszto es Szerviz Kft.
Organization address
address: ALSOTOROKVESZ 14 contact info |
HU (BUDAPEST) | participant | 1˙100˙000.00 |
| 3 |
UNIVERSITY COLLEGE LONDON
Organization address
address: GOWER STREET contact info |
UK (LONDON) | participant | 700˙000.00 |
| 4 |
MRI. TOOLS GMBH
Organization address
address: ROBERT ROSSLE STRASSE 10 contact info |
DE (BERLIN) | participant | 500˙000.00 |
| 5 |
FONDAZIONE BRUNO KESSLER
Organization address
address: VIA SANTA CROCE 77 contact info |
IT (TRENTO) | participant | 400˙000.00 |
| 6 |
CROMED KUTATO ES SZOLGALTATO KOZPONTOK KFT
Organization address
address: BAROSS UTCA 91 95 contact info |
HU (BUDAPEST) | participant | 350˙000.00 |
| 7 |
UNIVERSITA DEGLI STUDI DI MILANO
Organization address
address: Via Festa Del Perdono 7 contact info |
IT (MILANO) | participant | 270˙000.00 |
| 8 |
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Organization address
address: Via Olgettina 58 contact info |
IT (MILANO) | participant | 250˙000.00 |
| 9 |
NUCLEARFIELDS INTERNATIONAL BV
Organization address
address: AKKERVOORTWEG 7-11 contact info |
NL (VORTUM MULLEM) | participant | 200˙000.00 |
| 10 |
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Organization address
address: Via Giuseppe Mussi 1 contact info |
IT (MILANO) | participant | 115˙000.00 |
Mappa
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Obiettivo del progetto (Objective)
'The purpose of the project INSERT is to provide clinically relevant stratification and improved personalized radio-chemo therapy for brain tumour patients using a specifically developed multi-modality imaging tool. The system will also be used for early assessment of treatment efficacy. The initial focus will be on patients with glioma but there is future potential to target a range of tumours in the head and neck region. The proposed system is based on the development of a novel SPECT (Single Photon Emission Computed Tomography) system, suitable for insertion in the bore of an existing MRI (Magnetic Resonance Imaging) system, a cost-effective solution for widespread application. The combined system will allow the simultaneous measurement of anatomical (MRI) and functional (SPECT & MRI) information and the evaluation of their correlation in space and time. The SPECT design will enable acquisition of fast dynamic studies, with possibility for simultaneous measurement using multiple radionuclides (emitting at different energies), a distinct advantage compared to positron emission tomography (PET). This property can allow in-vivo simultaneous visualisation of spectrally resolved molecular and biochemical tumour properties. The stationary SPECT system is based on recently developed innovative gamma-ray detectors made with Silicon Drift Photodetectors, technology that achieves high-spatial resolution and is compatible with MRI thanks to the use of a silicon photodetector instead of photomultiplier tubes. The multi-modality SPECT/MRI imaging here proposed will apply a fully translational, vertical integration of research and development from technology design through preclinical models to clinical validation.'
Introduzione (Teaser)
Cancer diagnosis and progression monitoring present significant medical challenges. Advanced, non-invasive imaging methods are therefore needed to monitor the outcome of cancer treatment.