GLYCOBIOM

Tools for the Detection of Novel Glyco-biomarkers

Coordinatore	THE UNIVERSITY OF MANCHESTER    more  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Prof. Nome: Sabine Cognome: Flitsch Email: send email Telefono: 441613000000 Fax: 441613000000
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	6˙806˙915 €
EC contributo	5˙199˙099 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2010-two-stage
Funding Scheme	CP-FP
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE UNIVERSITY OF MANCHESTER  Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL contact info Titolo: Prof. Nome: Sabine Cognome: Flitsch Email: send email Telefono: 441613000000 Fax: 441613000000	UK (MANCHESTER)	coordinator	1˙552˙967.25
2	National Institute for Bioprocessing Research and Training Ltd  Organization address address: "Engineering Building, Belfield 125" city: Dublin postcode: 4 contact info Titolo: Prof. Nome: Pauline Cognome: Rudd Email: send email Telefono: +353 171 66 728 Fax: +353 171 66 950	IE (Dublin)	participant	1˙097˙230.75
3	UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF  Organization address address: Martinistrasse 52 city: HAMBURG postcode: 20246 contact info Titolo: Prof. Nome: Christoph Cognome: Wagener Email: send email Telefono: +49 40 7410 52981 Fax: +49 40 7410 54621	DE (HAMBURG)	participant	838˙700.00
4	GENOS DOO ZA VJESTACENJE I ANALIZU  Organization address address: Vatrogasna 112 city: Osijek postcode: 31000 contact info Titolo: Prof. Nome: Gordan Cognome: Lauc Email: send email Telefono: 38512352660 Fax: 38512352663	HR (Osijek)	participant	627˙802.00
5	KOBENHAVNS UNIVERSITET	DK	participant	602˙399.00
6	GALAB LABORATORIES GMBH  Organization address address: MAX PLANCK STRASSE 1 city: GEESTHACHT postcode: 21502 contact info Titolo: Dr. Nome: Juergen Cognome: Kuballa Email: send email Telefono: +49 4152 889 410 Fax: +49 4152 889 401	DE (GEESTHACHT)	participant	480˙000.00

Mappa

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 Obiettivo del progetto (Objective)

'Glycosylation patterns on glycoproteins and glycolipids are involved in the regulation of inter- and intracellular recognition events and alteration of such glycosylation has been observed in many diseases, notably in a variety of cancers. We propose that a systematic, large scale investigation in this area will provide a rich spectrum of novel and structurally diverse carbohydrate-based highly specific biomarkers. The aim of this project will be to address current bottlenecks in analytical techniques by developing an integrated multidisciplinary approach to glycobiomarker screening and analysis based on current state-of-the-art. We will bring together a number of complementary screening techniques developed in the individual partner laboratories, notably high-throughput LC-ms analysis of carbohydrates, lectins and carbohydrate arrays, to develop an overall workflow for the multiplex analysis of glycobiomarkers. Such carbohydrate-targeted methods will be combined with RNA/DNA and analysis (combining high throughput glycomics with genomics). It will be important to test the workflow against serum and tissue samples of healthy volunteer/cancer patients. In addition, we envisage that the project will generate new analytical tools that can be used in routine analysis of glycobiomarkers in the clinic, including diagnostic imaging. Some of the tools developed in this programme (lectins conjugated to nonoparticles) should also be useful for new quantitative imaging biomarkers for monitoring therapeutic effects and safety in cancer. The involvement of three SME partners will ensure that the technology is compatible with commercial applications.'