MIMOMICS
Methods for Integrated analysis of Multiple Omics datasets
| Coordinatore | ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 7˙883˙081 € |
| EC contributo | 5˙993˙308 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2012-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-10-01 - 2017-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | coordinator | 1˙614˙094.00 |
| 2 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Organization address
address: Ingolstaedter Landstrasse 1 contact info |
DE (MUENCHEN) | participant | 451˙519.00 |
| 3 |
THE UNIVERSITY OF MANCHESTER
Organization address
address: OXFORD ROAD contact info |
UK (MANCHESTER) | participant | 451˙099.60 |
| 4 |
UNIVERSITEIT HASSELT
Organization address
address: MARTELARENLAAN 42 contact info |
BE (Hasselt) | participant | 433˙600.00 |
| 5 |
PHARMATICS LIMITED
Organization address
address: "9 Little France Road, Edinburgh BioQuarter" contact info |
UK (EDINBURGH) | participant | 405˙700.00 |
| 6 |
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA
Organization address
address: Via Zamboni 33 contact info |
IT (BOLOGNA) | participant | 376˙756.00 |
| 7 |
GENEXPLAIN GMBH
Organization address
address: AM EXER 10 B contact info |
DE (WOLFENBUTTEL) | participant | 347˙800.00 |
| 8 |
BIOCOMPUTING PLATFORMS LTD OY
Organization address
address: TEKNIIKANTIE 14 contact info |
FI (ESPOO) | participant | 344˙640.00 |
| 9 |
GENOS DOO ZA VJESTACENJE I ANALIZU
Organization address
address: Vatrogasna 112 contact info |
HR (Osijek) | participant | 289˙350.00 |
| 10 |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
IT (ROMA) | participant | 259˙400.00 |
| 11 |
AULCHENKO YURY SERGEYEVICH
Organization address
address: DE SAVORNIN LOHMANLAAN 19 A contact info |
NL (GRONINGEN) | participant | 254˙400.00 |
| 12 |
THE UNIVERSITY OF EDINBURGH
Organization address
address: OLD COLLEGE, SOUTH BRIDGE contact info |
UK (EDINBURGH) | participant | 227˙447.00 |
| 13 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Organization address
address: The Old Schools, Trinity Lane contact info |
UK (CAMBRIDGE) | participant | 217˙000.40 |
| 14 |
TERVEYDEN JA HYVINVOINNIN LAITOS
Organization address
address: MANNERHEIMINTIE 166 contact info |
FI (HELSINKI) | participant | 208˙200.00 |
| 15 |
ACOUSTICVIEW LTD
Organization address
address: ELIYAHU HAKIM STR 14 - suite 32 contact info |
IL (TEL AVIV) | participant | 112˙302.00 |
Mappa
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Obiettivo del progetto (Objective)
'MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with novel findings so far. Support for methodological development is missing. The state-of-the-art methodology does not match by far the complexity of the biological problem. Complex data are being analysed in a rather simple way which misses the opportunity to uncover combinations of predictive profiles among the omics data. The objectives of MIMOmics are: to develop a statistical framework of methods for all analysis steps needed for identifying and interpreting omics-based biomarkers; and to integrate data derived from multiple omics platforms across several study designs and populations. Specific steps include: experimental design; pipelines for data gathering; cleaning of noisy spectra; predictive modeling of biomarkers; meta analysis; and causality assessment. To enhance our understanding, systems approaches will be considered for pathways and structural modelling of biological networks. The major challenge in the joint analysis of omics datasets will be to develop methods that deal with the high dimensionality, noisy spectral data, heterogeneity, and structure of these datasets. To perform these tasks successfully we bring together established EU academic and industrial researchers in metabolomics, glycomics, biostatistics, bioinformatics, scientific computing and epidemiology, with complementary expertise. A key feature of our project is the validation of novel methodology by performing a proof of principle (Metabolic Health) . Special effort will be made for rapid uptake of methods by communication with associated consortia and development of user-friendly software'