TRIGGER

"King of hearts, joints and lungs; periodontal pathogens as etiologic factor in RA, CVD and COPD and their impact on treatment strategies."

Coordinatore	UNIVERSITETET I BERGEN    more  Organization address address: Museplassen 1 city: BERGEN postcode: 5007 contact info Titolo: Ms. Nome: Liv-Grethe Cognome: Gudmundsen Email: send email Telefono: 4755584965 Fax: 4755584991
Nazionalità Coordinatore	Norway [NO]
Totale costo	7˙837˙584 €
EC contributo	5˙982˙363 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2012-INNOVATION-1
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-04-01   -   2017-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITETET I BERGEN  Organization address address: Museplassen 1 city: BERGEN postcode: 5007 contact info Titolo: Ms. Nome: Liv-Grethe Cognome: Gudmundsen Email: send email Telefono: 4755584965 Fax: 4755584991	NO (BERGEN)	coordinator	1˙108˙000.00
2	UNIWERSYTET JAGIELLONSKI  Organization address address: Ul. Golebia 24 city: KRAKOW postcode: 31007 contact info Titolo: Ms. Nome: Agata Cognome: Potempa Email: send email Telefono: 48126646156 Fax: 48126646209	PL (KRAKOW)	participant	586˙120.00
3	AARHUS UNIVERSITET  Organization address address: Nordre Ringgade 1 city: AARHUS C postcode: 8000 contact info Titolo: Ms. Nome: Pernille Leth Cognome: Stentov Email: send email Telefono: 4587152997	DK (AARHUS C)	participant	558˙042.00
4	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Caroline Cognome: Hamilton Email: send email Telefono: 46851775959 Fax: 468337394	SE (STOCKHOLM)	participant	532˙800.00
5	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Mr. Nome: Alberto Cognome: Sereno Alvarez Email: send email Telefono: 34915668852 Fax: 34915668913	ES (MADRID)	participant	519˙041.00
6	THE UNIVERSITY OF BIRMINGHAM  Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT contact info Titolo: Ms. Nome: May Cognome: Chung Email: send email Telefono: 441214000000 Fax: 441214000000	UK (BIRMINGHAM)	participant	496˙000.00
7	FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V  Organization address address: Hansastrasse 27C city: MUENCHEN postcode: 80686 contact info Titolo: Ms. Nome: Andrea Cognome: Zeumann Email: send email Telefono: +49 89 1205 2723 Fax: +49 89 1205 7534	DE (MUENCHEN)	participant	484˙510.00
8	HADASSAH MEDICAL ORGANIZATION  Organization address address: n/a city: JERUSALEM postcode: 91120 contact info Titolo: Dr. Nome: Hadas Cognome: Lemberg Email: send email Telefono: 97226776095 Fax: 97226434701	IL (JERUSALEM)	participant	483˙600.00
9	UNIVERSITETET I OSLO  Organization address address: Problemveien 5-7 city: OSLO postcode: 313 contact info Titolo: Mr. Nome: Per Arenfeldt Cognome: Omdal Email: send email Telefono: 4722840347	NO (OSLO)	participant	466˙590.00
10	UNIVERSITAET BERN  Organization address address: Hochschulstrasse 4 city: BERN postcode: 3012 contact info Titolo: Dr. Nome: Sigrun Cognome: Eick Email: send email Telefono: 41316322542 Fax: 41316328608	CH (BERN)	participant	448˙000.00
11	ANAXOMICS BIOTECH, S.L.  Organization address address: CALLE BALMES (PISO 4 - PTA 2A) 89 city: Barcelona postcode: 8008 contact info Titolo: Mrs. Nome: Vesna Cognome: Radovanovic Email: send email Telefono: 34934516717	ES (Barcelona)	participant	299˙660.00

Mappa

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 Obiettivo del progetto (Objective)

'Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwide suffers from severe periodontitis , the impact of this disease on human health is immense and has been recognized by World Health Organization . Nevertheless, in many EU countries PD is a neglected disease, both by the population in general and health-care personnel. Often this negligence comes to the point that, like a hair-loss, the tooth-loss due to periodontitis is still considered as a normal inevitable event associated with aging. To combat this misconception and conceive novel approaches to prevent and/or treat CVD, RA, and COPD we will explore highly innovative ideas that these non-communicable diseases are at least aggravated, if not initiated, by periodontal infection. Results emanating from our project will: i) elucidate a relationship between the presence of specific periodontal pathogens and severity of systemic diseases; ii) show that extensive periodontal treatment improves clinical parameters of investigated systemic diseases; iii) reveal the impact of eradication of specific periodontal pathogen on the level of inflammatory markers; iv) develop novel, periodontal-pathogen specific bactericidal compounds based on periodontal glutaminyl cyclase (QC), the enzyme essential for these pathogens vitality. This will reduce mortality and ameliorated quality of life of CVD, RA, and COPD patients. All of these will be possible based on the knowledge of mechanisms beyond the causative links between specific pathogen driven periodontal disease and CVD, RA, and COPD revealed by research program outlined in this project.'