TRIGGER
"King of hearts, joints and lungs; periodontal pathogens as etiologic factor in RA, CVD and COPD and their impact on treatment strategies."
| Coordinatore | UNIVERSITETET I BERGEN
Organization address
address: Museplassen 1 contact info |
| Nazionalità Coordinatore | Norway [NO] |
| Totale costo | 7˙837˙584 € |
| EC contributo | 5˙982˙363 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2012-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-04-01 - 2017-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITETET I BERGEN
Organization address
address: Museplassen 1 contact info |
NO (BERGEN) | coordinator | 1˙108˙000.00 |
| 2 |
UNIWERSYTET JAGIELLONSKI
Organization address
address: Ul. Golebia 24 contact info |
PL (KRAKOW) | participant | 586˙120.00 |
| 3 |
AARHUS UNIVERSITET
Organization address
address: Nordre Ringgade 1 contact info |
DK (AARHUS C) | participant | 558˙042.00 |
| 4 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 532˙800.00 |
| 5 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 519˙041.00 |
| 6 |
THE UNIVERSITY OF BIRMINGHAM
Organization address
address: Edgbaston contact info |
UK (BIRMINGHAM) | participant | 496˙000.00 |
| 7 |
FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V
Organization address
address: Hansastrasse 27C contact info |
DE (MUENCHEN) | participant | 484˙510.00 |
| 8 |
HADASSAH MEDICAL ORGANIZATION
Organization address
address: n/a contact info |
IL (JERUSALEM) | participant | 483˙600.00 |
| 9 |
UNIVERSITETET I OSLO
Organization address
address: Problemveien 5-7 contact info |
NO (OSLO) | participant | 466˙590.00 |
| 10 |
UNIVERSITAET BERN
Organization address
address: Hochschulstrasse 4 contact info |
CH (BERN) | participant | 448˙000.00 |
| 11 |
ANAXOMICS BIOTECH, S.L.
Organization address
address: CALLE BALMES (PISO 4 - PTA 2A) 89 contact info |
ES (Barcelona) | participant | 299˙660.00 |
Mappa
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Obiettivo del progetto (Objective)
'Extensive clinical and epidemiological data clearly shows that chronic periodontal disease (PD), the most prevalent infectious inflammatory disease of mankind, is strongly linked to systemic inflammatory diseases such as cardiovascular diseases (CVD) , rheumatoid arthritis (RA) , and chronic obstructive pulmonary disease (COPD) . Taking into account that up to 30% of the adult population worldwide suffers from severe periodontitis , the impact of this disease on human health is immense and has been recognized by World Health Organization . Nevertheless, in many EU countries PD is a neglected disease, both by the population in general and health-care personnel. Often this negligence comes to the point that, like a hair-loss, the tooth-loss due to periodontitis is still considered as a normal inevitable event associated with aging. To combat this misconception and conceive novel approaches to prevent and/or treat CVD, RA, and COPD we will explore highly innovative ideas that these non-communicable diseases are at least aggravated, if not initiated, by periodontal infection. Results emanating from our project will: i) elucidate a relationship between the presence of specific periodontal pathogens and severity of systemic diseases; ii) show that extensive periodontal treatment improves clinical parameters of investigated systemic diseases; iii) reveal the impact of eradication of specific periodontal pathogen on the level of inflammatory markers; iv) develop novel, periodontal-pathogen specific bactericidal compounds based on periodontal glutaminyl cyclase (QC), the enzyme essential for these pathogens vitality. This will reduce mortality and ameliorated quality of life of CVD, RA, and COPD patients. All of these will be possible based on the knowledge of mechanisms beyond the causative links between specific pathogen driven periodontal disease and CVD, RA, and COPD revealed by research program outlined in this project.'