EPINER2007

Epigenetics and DNA repair. Is a chromatin remodeling process involved in the higher UV sensitivity of nucleotide excision repair defective cells?

Coordinatore	INSTITUTO DE INVESTIGACIONES BIOLOGICAS CLEMENTE ESTABLE    more  Organization address address: AV. ITALIA 3318 city: MONTEVIDEO postcode: 11600 contact info Titolo: Ms. Nome: María Del Carmen Cognome: Ruzic Email: send email Telefono: (5982) 487 16 16/108 Fax: (5982) 487 54 61
Nazionalità Coordinatore	Uruguay [UY]
Totale costo	15˙000 €
EC contributo	15˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-4-2-IIF
Funding Scheme	MC-IIFR
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-06-01   -   2011-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUTO DE INVESTIGACIONES BIOLOGICAS CLEMENTE ESTABLE  Organization address address: AV. ITALIA 3318 city: MONTEVIDEO postcode: 11600 contact info Titolo: Ms. Nome: María Del Carmen Cognome: Ruzic Email: send email Telefono: (5982) 487 16 16/108 Fax: (5982) 487 54 61	UY (MONTEVIDEO)	coordinator	15˙000.00

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 Obiettivo del progetto (Objective)

'The knowledge on regulatory roles of epigenetic mechanisms (heritable changes in the genome function without a change in the DNA sequence) has grown very fast during the last decade since they can be the target for treating several pathologies related to cancer and neurodegeneration. In the base of these diseases deficiencies in DNA repair mechanisms have also been found. In this respect, two human syndromes (Xeroderma Pigmentosum and Cockayne’s Syndrome) affecting one of the major DNA repair systems in human cells called nucleotide excision repair (NER) characterized by sensitivity to UV irradiation, are interesting models to unravel the link between chromatin remodeling processes and DNA repair. Expected results on the possible influence of chromatin remodeling processes on the higher sensitivity to UV radiation of Cockayne’s Syndrome cells will allow further investigations in order to understand how these mechanisms are involved in the development of cancer and/or neurodegeneration found in these patients. Since the proposed investigation requires a multidisciplinary study (cytogenetics, molecular biology and immunocytochemistry), it is of the utmost importance not only for the planned research activity at the Laboratory of Prof. Palitti (since this line of research fits very well with the purposes already established by the Network of Excellence - NoE – Epigenetic Network created by several laboratories from Europe and supported by the FP6 Program from the European Community) but also for having the possibility to incorporate new methodologies and strategies to continue with the study of possible links between epigenetic and DNA repair in our laboratory in Uruguay with the aim to initiate studies on epigenetic therapy mainly applied to facilitate chemotherapy treatment of cancer diseases.'