EUROSTAM
A Europe-wide Strategy to enhance Transplantation of highly sensitized patients on basis of Acceptable HLA Mismatches
| Coordinatore | ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
| Nazionalità Coordinatore | Netherlands [NL] |
| Totale costo | 3˙737˙167 € |
| EC contributo | 2˙623˙500 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2012-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2012 |
| Periodo (anno-mese-giorno) | 2012-12-01 - 2015-11-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | coordinator | 777˙900.00 |
| 2 |
MULTIPLICOM NV
Organization address
address: GALILEILAAN 18 contact info |
BE (NIEL) | participant | 474˙400.00 |
| 3 |
NHS BLOOD AND TRANSPLANT
Organization address
address: OAK HOUSE REEDS CRESCENT contact info |
UK (WATFORD) | participant | 303˙500.00 |
| 4 |
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Organization address
address: CALLE ROSSELLO 149 PUERTA BJS contact info |
ES (BARCELONA) | participant | 278˙000.00 |
| 5 |
Nome Ente NON disponibile
Organization address
address: Videnska 1958/9 contact info |
CZ (PRAGUE 4) | participant | 213˙200.00 |
| 6 |
ABSORBER AB
Organization address
address: FRANZENGATAN 5 contact info |
SE (STOCKHOLM) | participant | 210˙500.00 |
| 7 |
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST
Organization address
address: PRESCOT STREET contact info |
UK (LIVERPOOL) | participant | 137˙000.00 |
| 8 |
UNIVERSITE DE GENEVE
Organization address
address: Rue du General Dufour 24 contact info |
CH (GENEVE) | participant | 137˙000.00 |
| 9 |
STICHTING EUROTRANSPLANT INTERNATIONAL FOUNDATION
Organization address
address: PLESMANLAAN 100 contact info |
NL (LEIDEN) | participant | 92˙000.00 |
| 10 |
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
Organization address
address: 3 Avenue Victoria contact info |
FR (PARIS) | participant | 0.00 |
| 11 |
GENERAL HOSPITAL OF ATHENS G.GENNIMATAS GGHA
Organization address
address: MESOGEION AVENUE 154 contact info |
EL (ATHINA) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'The presence of donor specific HLA antibodies is a contra-indication for renal transplantation. Highly sensitized patients accumulate and often die on the transplant waiting lists as it is almost impossible to find donors towards which they don’t have antibodies. The acceptable mismatch program of Eurotransplant has shown to be an effective tool to enhance successful transplantation of highly sensitized patients. However, 35% of the patients have rare HLA phenotypes and no suitable donor can be found. HLA phenotype frequencies vary amongst European populations. Rare HLA phenotypes in one population are more frequent in other populations. The major objective of the 10 partners in this project is to analyze the feasibility and requirements for a Europe-wide acceptable mismatch program to enhance transplantation of patients with rare HLA phenotypes in their own population. Long waiting patients will be matched with virtual donors based on known HLA frequencies of different European populations and with actual donors from the different transplant organizations. If successful, the logistics will be tested by transplanting some of these patients with donors from elsewhere in Europe. Second objective is to simplify the definition of acceptable HLA mismatches. Although almost 4000 HLA class I antigens are known, only 150 polymorphic residues differentially spread over the different HLA antigens are responsible for the induction of antibodies. An innovative typing and matching strategy based on the definition of acceptable HLA epitopes will facilitate the identification of suitable donors. Third objective is to define whether antibodies against non-HLA targets on the donor endothelium affect the results of transplants in highly sensitized patients. The aims of this collaborative project are fully compatible with those required for the program Health.2012.1.4-1. In objectives 2 and 3 two partners belonging to the SME sector of the European industry are involved.'
Introduzione (Teaser)
The success of organ transplantation is highly dependent on matching the donor organ with the recipient. A pan-European innovative typing and matching should enhance the identification of suitable donors.