NANOTEST

Development of methodology for alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics

Coordinatore	NORSK INSTITUTT FOR LUFTFORSKNING    more  Organization address address: Instituttveien 18 city: KJELLER postcode: 2027 contact info Titolo: Dr. Nome: Maria Cognome: Dusinska Email: send email Telefono: +47 63 89 80 00 Fax: +47 63 89 80 50
Nazionalità Coordinatore	Norway [NO]
Totale costo	3˙933˙271 €
EC contributo	2˙994˙383 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-04-01   -   2012-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	NORSK INSTITUTT FOR LUFTFORSKNING  Organization address address: Instituttveien 18 city: KJELLER postcode: 2027 contact info Titolo: Dr. Nome: Maria Cognome: Dusinska Email: send email Telefono: +47 63 89 80 00 Fax: +47 63 89 80 50	NO (KJELLER)	coordinator	0.00
2	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""  Organization address address: Patriarchou Gregoriou Str. city: AGHIA PARASKEVI postcode: 15310 contact info Titolo: Ms. Nome: Stella Cognome: Martaki Email: send email Telefono: +30 210 650 3036 Fax: +30 210 6522623	EL (AGHIA PARASKEVI)	participant	0.00
3	ACONDICIONAMIENTO TARRASENSE ASSOCIACION  Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 contact info Titolo: Dr. Nome: Izabel Cognome: Alfany Email: send email Telefono: +34 93 788 23 00	ES (TERRASSA)	participant	0.00
4	ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES S.A.  Organization address address: C/Baldiri Reixac 10-12 city: BARCELONA postcode: 8028 contact info Titolo: Dr. Nome: Luis Cognome: Ruiz Avila Email: send email Telefono: +34 93 4037011 Fax: +34 93 4039956	ES (BARCELONA)	participant	0.00
5	HOSPICES CANTONAUX CHUV  Organization address address: Rue du Bugnon 21 city: LAUSANNE postcode: 1005 contact info Titolo: Mr. Nome: Bernard Cognome: Gmünder Email: send email Telefono: +41 21 314 1686 Fax: +41 21 314 7205	CH (LAUSANNE)	participant	0.00
6	INSTITUTE OF OCCUPATIONAL MEDICINE  Organization address address: Research Avenue North, Riccarton 45 city: EDINBURGH postcode: EH14 4AP contact info Titolo: Ms. Nome: Susy Cognome: Scarisbrick Email: send email Telefono: +44 0 131 4498065 Fax: +44 0 870 850 5132	UK (EDINBURGH)	participant	0.00
7	JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION  Organization address address: Rue de la Loi 200 city: BRUSSELS postcode: 1049 contact info Titolo: Mr. Nome: Raymond Cognome: Crandon Email: send email Telefono: +39 0332789988 Fax: +39 0332785730	BE (BRUSSELS)	participant	0.00
8	KOBENHAVNS UNIVERSITET	DK	participant	0.00
9	SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE  Organization address address: LIMBOVA 12 city: BRATISLAVA postcode: 83303 contact info Titolo: Mr. Nome: Milan Cognome: Cagá? Email: send email Telefono: +421 259370650 Fax: +421 259370652	SK (BRATISLAVA)	participant	0.00
10	UNIVERSITA CA' FOSCARI VENEZIA  Organization address address: DORSODURO 3246 city: VENEZIA postcode: 30123 contact info Titolo: Mr. Nome: Emanuele Cognome: Argese Email: send email Telefono: +39 041 2348565 Fax: +39 041 2348584	IT (VENEZIA)	participant	0.00
11	UNIVERSITE PARIS DIDEROT - PARIS 7  Organization address address: RUE THOMAS MANN 5 city: PARIS postcode: 75205 contact info Titolo: Ms. Nome: Muriel Cognome: Maurice Email: send email Telefono: +33 1 57 27 55 48 Fax: +33 1 57 27 55 47	FR (PARIS)	participant	0.00
12	University Hospitals Bristol NHS Foundation Trust  Organization address address: "Trust Headquarters, Marlborough Street" city: BRISTOL postcode: BS13NU contact info Titolo: Dr. Nome: Margaret Cognome: Saunders Email: send email Telefono: +44 117 928 2984 Fax: +44 117 928 2470	UK (BRISTOL)	participant	0.00

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Nanoparticles (NP) have unique, potentially beneficial properties, but their possible impact on human health has not been adequately assessed. The main goal of this proposal is to develop alternative high-throughput testing strategies using in vitro and in silico methods to assess the toxicological profile of NP used in medical diagnostics. Our specific aims are to: 1. Define NP properties and fully characterize NP to be used 2. Study NP interactions with molecules, cells and organs and develop in vitro methods to study the toxicological potential of NP 3. Validate in vitro findings in short-term in vivo models and study particle effects in animals and (ex vivo) in humans to assess individual susceptibility to NP 4. Develop in silico models of NP interactions Experimental work is structured in 4 WPs to address NP characterisation and key elements in evaluation of NP uptake, exposure and toxicology. NANOTEST integrates the investigation of toxicological properties and effects of NP in several target systems by developing a battery of in vitro assays using cell cultures, organotypic cell culture and small organ fragments (ex vivo) derived from different biological systems; blood, vascular system, liver, lung, placenta, digestive and central nervous systems. As NP action is likely to involve oxidative stress we will focus on the cross-cutting areas of inflammation, cellular toxicity, immunotoxicity, genotoxicity and related endpoints. Following development of SOP and generation of a common database and in parallel with in silico assays (QSAR, PBPK modelling), NanoTest will evaluate toxic effects and interactions of NP used in nanomedicine. Results will be validated in an experimental ethically approved in vivo model. The most advanced and standardised techniques will be adapted for automation and prepared for validation by ECVAM. Separate WPs will be dedicated to dissemination and to effective administrative and scientific management.'