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IDentIFY SIGNED

Improving Diagnosis by Fast Field-Cycling MRI

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

IDentIFY project word cloud

Explore the words cloud of the IDentIFY project. It provides you a very rough idea of what is the project "IDentIFY" about.

create engineering healthcare extend ffc diagnosis relaxation thromboembolic sensitivity agents mri clinical mechanisms sequences generate sarcopenia contrast cancer world consolidates shifting scanning adoption solution switch molecular magnetic lower monitor invisible understand diagnostic informing quantitative radiofrequency power tissue stabilise biomarkers scanners paradigm tissues patient monitoring demonstrated solved physics ultra surgery many solutions correction correct diseases models pulse diagnosed cycling innovations theory stability environmental patients vitro arise examples signals magnet contributes fast teams scans unmet inadequately disease coils sustainability acquisition samples proof obtaining decisions banks supply uses chemistry treatment imaging magnetometers osteoarthritis standard

Project "IDentIFY" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX website: http://www.abdn.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.identify-project.eu
Total cost	6˙597˙377 €
EC max contribution	6˙597˙377 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX website: http://www.abdn.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABERDEEN)	coordinator	1˙479˙853.00
2	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	1˙173˙041.00
3	STELAR SRL STELAR SRL Organization address address: VIA ENRICO FERMI 4 city: MEDE postcode: 27035 website: www.stelar.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MEDE)	participant	902˙750.00
4	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	633˙625.00
5	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	584˙750.00
6	TECHNISCHE UNIVERSITAET ILMENAU TECHNISCHE UNIVERSITAET ILMENAU Organization address address: EHRENBERGSTRASSE 29 city: ILMENAU postcode: 98693 website: www.tu-ilmenau.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ILMENAU)	participant	442˙250.00
7	OY INTERNATIONAL ELECTRIC COMPANY OY INTERNATIONAL ELECTRIC COMPANY Organization address address: SAHAAJANKATU 48 city: HELSINKI postcode: 880 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	437˙081.00
8	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	367˙560.00
9	UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE Organization address address: UL. OCZAPOWSKIEGO 2 city: OLSZTYN postcode: 10 719 website: www.uwm.edu.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (OLSZTYN)	participant	321˙000.00
10	INTERNATIONAL ELECTRIC COMPANY OY INTERNATIONAL ELECTRIC COMPANY OY Organization address address: SAHAAJANKATU 48 city: HELSINKI postcode: 880 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	255˙466.00

Map

Project objective

Many diseases are inadequately diagnosed, or not diagnosed early enough by current imaging methods. Examples of unmet clinical needs arise in thromboembolic disease, osteoarthritis, cancer, sarcopenia, and many more areas. Our solution, Fast Field-Cycling (FFC) MRI, can measure quantitative information that is invisible to standard MRI. FFC scanners switch magnetic field while scanning the patient, obtaining new diagnostic information. FFC-MRI has been demonstrated by us, but many challenges must be solved before clinical adoption. Objectives: Understand the mechanisms determining FFC signals in tissues; Create technology to measure and correct for environmental magnetic fields, enabling FFC at ultra-low fields; Investigate contrast agents for FFC, to increase sensitivity and to allow molecular imaging; Improve FFC technology, in order to extend its range of clinical applications; Test FFC-MRI on tissue samples and on patients. Achieved by: Developing the theory of relaxation in tissue at ultra-low fields, leading to models and biomarkers; Developing magnetometers for FFC-MRI, and environmental-field correction; Creating and in vitro testing of new FFC contrast agents; studying existing clinical agents for FFC-MRI sensitivity; Improving technology to monitor and stabilise magnetic fields in FFC; improving magnet power supply stability; investigating better radiofrequency coils and acquisition pulse sequences; Testing FFC methods on tissue samples from surgery and tissue banks; proof-of-principle scans on patients. FFC-MRI is a paradigm-shifting technology which will generate new, quantitative disease biomarkers, directly informing and improving clinical diagnosis, treatment decisions and treatment monitoring. Its lower cost contributes to healthcare sustainability. The proposal consolidates the EU lead in FFC technology and uses new concepts from world-leading teams to deliver solutions based on innovations in theory, modelling, physics, chemistry and engineering.

Deliverables

List of deliverables.
Amplifier stability measurement techniques	Demonstrators, pilots, prototypes	2019-05-31 11:39:11
Upgraded FFC-NMR relaxometers	Demonstrators, pilots, prototypes	2019-05-31 11:39:08
Analytical models of environmental magnetic fields	Documents, reports	2019-05-31 11:39:12
Lowâ€field correction coils	Demonstrators, pilots, prototypes	2019-05-31 11:39:12
Currently-approved contrast agents for FFC-MRI	Documents, reports	2019-05-31 11:39:12
Theory of relaxation processes	Demonstrators, pilots, prototypes	2019-05-31 11:39:10
Array RF coils and receivers for FFC-MRI	Demonstrators, pilots, prototypes	2019-05-31 11:39:12
FFC-NMR and FFC-MRI protocols	Documents, reports	2019-05-31 11:39:14
Speed-up of FFC-MRI	Demonstrators, pilots, prototypes	2019-05-31 11:39:12
First study subject approvals package	Documents, reports	2019-05-31 11:39:11
Surface RF coil for relaxometer	Demonstrators, pilots, prototypes	2019-05-30 13:16:19
Magnetic field mapping and correction with existing coils	Documents, reports	2019-05-30 13:16:23
Numerical tool for non-exponential relaxation analysis	Demonstrators, pilots, prototypes	2019-05-30 13:16:22
Magnetic field sensor survey	Documents, reports	2019-05-30 13:16:22

Take a look to the deliverables list in detail: detailed list of IDentIFY deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Danuta Kruk, Elzbieta Masiewicz, Milosz Wojciechowski, Malgorzata Florek-Wojciechowska, Lionel M. Broche, David J. Lurie Slow dynamics of solid proteins - Nuclear Magnetic Resonance relaxometry versus Dielectric Spectroscopy published pages: 106721, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2020.106721	Journal of Magnetic Resonance	2020-04-15
2020	Hassan Abbas, Lionel M. Broche, Aiarpi Ezdoglian, Dmitriy Li, Raif Yuecel, P. James Ross, Lesley Cheyne, Heather M. Wilson, David J. Lurie, Dana K. Dawson Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept published pages: 106722, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2020.106722	Journal of Magnetic Resonance 313	2020-04-15
2020	Simona Baroni, Maria Rosaria Ruggiero, Valeria Bitonto, Lionel M. Broche, David J. Lurie, Silvio Aime, Simonetta Geninatti Crich In vivo assessment of tumour associated macrophages in murine melanoma obtained by low-field relaxometry in the presence of iron oxide particles published pages: 119805, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2020.119805	Biomaterials 236	2020-02-13
2019	Danuta Kruk, Elzbieta Masiewicz, Anna M. Borkowska, Pawel Rochowski, Pascal H. Fries, Lionel M. Broche, David J. Lurie Dynamics of Solid Proteins by Means of Nuclear Magnetic Resonance Relaxometry published pages: 652, ISSN: 2218-273X, DOI: 10.3390/biom9110652	Biomolecules 9/11	2020-01-29
2019	Danuta Kruk, Pawel Rochowski, Elzbieta Masiewicz, Slawomir Wilczynski, Milosz Wojciechowski, Lionel M. Broche, David J. Lurie Mechanism of Water Dynamics in Hyaluronic Dermal Fillers Revealed by Nuclear Magnetic Resonance Relaxometry published pages: 2816-2822, ISSN: 1439-4235, DOI: 10.1002/cphc.201900761	ChemPhysChem 20/21	2020-01-29
2019	Maria Ruggiero, Diego Alberti, Valeria Bitonto, Simonetta Geninatti Crich Ferritin: A Platform for MRI Contrast Agents Delivery published pages: 33, ISSN: 2304-6740, DOI: 10.3390/inorganics7030033	Inorganics 7/3	2020-01-30
2019	Simona Baroni, Maria Rosaria Ruggiero, Silvio Aime, Simonetta Geninatti Crich Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent published pages: 845-851, ISSN: 0749-1581, DOI: 10.1002/mrc.4837	Magnetic Resonance in Chemistry 57/10	2020-01-29
2019	Enza Di Gregorio, Giuseppe Ferrauto, Stefania Lanzardo, Eliana Gianolio, Silvio Aime Use of FCC-NMRD relaxometry for early detection and characterization of ex-vivo murine breast cancer published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41154-9	Scientific Reports 9/1	2020-01-29
2018	Giuseppe Ferrauto, Enza Di Gregorio, Stefania Lanzardo, Laura Ciolli, Manuela Iezzi, Silvio Aime Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28926-5	Scientific Reports 8/1	2019-10-08
2019	Lionel M. Broche, P. James Ross, Gareth R. Davies, Mary-Joan MacLeod, David J. Lurie A whole-body Fast Field-Cycling scanner for clinical molecular imaging studies published pages: 10402, ISSN: 2045-2322, DOI: 10.1038/s41598-019-46648-0	Scientific Reports 9/1	2019-08-29
2018	Maria Rosaria Ruggiero, Simona Baroni, Silvio Aime, Simonetta Geninatti Crich Relaxometric investigations addressing the determination of intracellular water lifetime: a novel tumour biomarker of general applicability published pages: 1-7, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1527045	Molecular Physics	2019-04-30
2018	Pascal H. Fries, Elie Belorizky Theory of fast field-cycling NMR relaxometry of liquid systems undergoing chemical exchange published pages: 1-12, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1538539	Molecular Physics	2019-04-30
2019	Markus BÃ¶denler, Ludovic de Rochefort, P. James Ross, Nicolas Chanet, GeneviÃ¨ve Guillot, Gareth R. Davies, Christian GÃ¶sweiner, Hermann Scharfetter, David J. Lurie, Lionel M. Broche Comparison of fast field-cycling magnetic resonance imaging methods and future perspectives published pages: 1-17, ISSN: 0026-8976, DOI: 10.1080/00268976.2018.1557349	Molecular Physics	2019-04-30
2017	G. Galuppini, C. Toffanin, D.M. Raimondo, A. Provera, Y. Xia, R. Rolfi, G. Ferrante, L. Magni Towards a Model-Based Field-Frequency Lock for NMR published pages: 13020-13025, ISSN: 2405-8963, DOI: 10.1016/j.ifacol.2017.08.1999	IFAC-PapersOnLine 50/1	2019-04-30
2018	Oleg V. Petrov, Siegfried Stapf Multicomponent analysis of T 1 relaxation in bovine articular cartilage at low magnetic fields published pages: , ISSN: 0740-3194, DOI: 10.1002/mrm.27624	Magnetic Resonance in Medicine	2019-04-30
2018	Juan Carlos Cutrin, Diego Alberti, Caterina Bernacchioni, Silvia Ciambellotti, Paola Turano, Claudio Luchinat, Simonetta Geninatti Crich, Silvio Aime Cancer cell death induced by ferritins and the peculiar role of their labile iron pool published pages: 27974-27984, ISSN: 1949-2553, DOI: 10.18632/oncotarget.25416	Oncotarget 9/46	2019-04-30
2018	Maria Rosaria Ruggiero, Simona Baroni, Stefania Pezzana, Gianni Ferrante, Simonetta Geninattiâ€…Crich, Silvio Aime Evidence for the Role of Intracellular Water Lifetime as a Tumour Biomarker Obtained by Inâ€…Vivo Field-Cycling Relaxometry published pages: 7468-7472, ISSN: 1433-7851, DOI: 10.1002/anie.201713318	Angewandte Chemie International Edition 57/25	2019-04-30

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