MEMBRANENANOPART

Modelling the mechanisms of nanoparticle-lipid interactions and nanoparticle effects on cell membrane structure and function

Coordinatore	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN    more  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Dr. Nome: Vladimir Cognome: Lobaskin Email: send email Telefono: +353 1 7162432
Nazionalità Coordinatore	Ireland [IE]
Sito del progetto	http://www.membranenanopart.eu
Totale costo	1˙281˙035 €
EC contributo	999˙810 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2012-SMALL-6
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-01   -   2015-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN  Organization address address: BELFIELD city: DUBLIN postcode: 4 contact info Titolo: Dr. Nome: Vladimir Cognome: Lobaskin Email: send email Telefono: +353 1 7162432	IE (DUBLIN)	coordinator	355˙180.00
2	IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE  Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ contact info Titolo: Ms. Nome: Brooke Cognome: Alasya Email: send email Telefono: +44 207 594 1181	UK (LONDON)	participant	299˙989.00
3	STOCKHOLMS UNIVERSITET  Organization address address: Universitetsvaegen 10 city: STOCKHOLM postcode: 10691 contact info Titolo: Mr. Nome: Daniel Cognome: Emanuelsson Email: send email Telefono: +46 8 162374	SE (STOCKHOLM)	participant	284˙095.00
4	INSTITUTE OF BIOLOGY OF KARELIAN RESARCH CENTRE RUSSIAN ACADEMY OF SCIENCES  Organization address address: PUSHKINSKAYA STREET 11 city: PETROZAVODSK REPUBLIC OF KARELIA postcode: 185910 contact info Titolo: Prof. Nome: Alexander Cognome: Rabinovich Email: send email Telefono: +78 14 2769810	RU (PETROZAVODSK REPUBLIC OF KARELIA)	participant	60˙546.00

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 Obiettivo del progetto (Objective)

'The central goal of our proposal is to develop physically justified models and computational tools to quantitatively describe and understand the molecular mechanisms of nanoparticle-cell membrane interactions, which we consider to be a crucial point in any predictive model of nanoparticle toxicity. We consider mechanisms of nanoparticle protein corona formation, the protective function of the membrane, nanoparticle uptake into the cell, and the effect of nanoparticles on the cell membrane. We plan to develop a consistent multiscale simulation scheme starting from nanoparticle-biomolecule interaction at the atomistic scale using molecular dynamics simulation, and then systematically constructing coarse-grained mesoscale models for simulating the structure and dynamics of the cell membrane perturbed by nanoparticles at the physiologically relevant time and length scales. We will develop and test a universal method for evaluating the rates of nanoparticle translocation through membranes and evaluate associated specific toxicity effects. Based on the information acquired from the simulations and analyzed together with available experimental data, the toxicological impact will be deduced. We will apply our approach to a range of common engineered nanoparticles, relating their physicochemical properties such as size and shape, surface charge, hydrophobicity (logP), and plasma protein binding affinity to the toxicological effects and develop a test suite allowing to make toxicity prediction on the basis of purely computational or limited in vitro screening tests.'

Introduzione (Teaser)

Engineered nanoparticles (NPs) are enabling miniaturisation and functionalisation of devices in numerous fields. New models of toxicity and interactions at the level of the cell membrane will foster design of NPs safe for people and the environment.