MAGNETOGENETICS

Reverse engineering the vertebrate molecular machinery for magnetic biomineralisation

Coordinatore	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Germany [DE]
Totale costo	1˙469˙100 €
EC contributo	1˙469˙100 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2012-StG_20111109
Funding Scheme	ERC-SG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-01-01   -   2017-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN  Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 contact info Titolo: Ms. Nome: Renate Cognome: Rädlein Email: send email Telefono: +49 89 4140 2842	DE (MUENCHEN)	beneficiary	491˙900.00
2	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Juergen Cognome: Ertel Email: send email Telefono: +49 89 3187 3022 Fax: +49 89 3187 3866	DE (MUENCHEN)	hostInstitution	977˙200.00
3	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Prof. Nome: Gil Gregor Cognome: Westmeyer Email: send email Telefono: +49 89 3187 2123	DE (MUENCHEN)	hostInstitution	977˙200.00

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 Obiettivo del progetto (Objective)

'In order to understand distributed biological networks and invent effective molecular therapies, we need to be able to image and control molecular processes across entire live organisms. Although an arsenal of genetically encoded fluorescent sensors and light-activated proteins has recently been developed to visualize and manipulate cellular activity, these methods all suffer from the poor penetration of light through biological tissue, which makes them rather invasive for practical in vivo use in animal models and prevents whole-organ coverage. To overcome these substantial limitations of optical methods, I thus propose a reverse engineering project to functionally dissect the molecular machinery for magnetic biomineralisation in eukaryotic cells and build a new bioengineering platform for genetically controlled bio-magnetic interfaces. To achieve this goal, we will use a combination of magnetic cell sorting and biophysical characterization, targeted analysis and -omics approaches as well as genetic tools. This scientific program will break the ground for non-invasive sensing and actuation of molecular processes via magnetic fields based on genetic control over the biosynthesis of magnetic biominerals.'