LIFELONGJOINTS
Silicon Nitride Coatings for Improved Implant Function
| Coordinatore | UNIVERSITY OF LEEDS
Organization address
address: WOODHOUSE LANE contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 18˙286˙366 € |
| EC contributo | 13˙317˙000 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2012-LARGE-6 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-04-01 - 2018-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY OF LEEDS
Organization address
address: WOODHOUSE LANE contact info |
UK (LEEDS) | coordinator | 3˙256˙581.90 |
| 2 |
IHI IONBOND AG
Organization address
address: INDUSTRIESTRASSE 211 contact info |
CH (OLTEN) | participant | 1˙820˙427.80 |
| 3 |
Simulation Solutions Limited
Organization address
address: Rugby Park Bletchley Road Unit 10 contact info |
UK (Heaton Mersey) | participant | 1˙244˙160.00 |
| 4 |
UPPSALA UNIVERSITET
Organization address
address: SANKT OLOFSGATAN 10 B contact info |
SE (UPPSALA) | participant | 1˙154˙132.00 |
| 5 |
LINKOPINGS UNIVERSITET
Organization address
address: CAMPUS VALLA contact info |
SE (LINKOPING) | participant | 1˙058˙579.20 |
| 6 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH
Organization address
address: Raemistrasse 101 contact info |
CH (ZUERICH) | participant | 881˙231.60 |
| 7 |
AnyBody Technology A/S
Organization address
address: Niels Jernes Vej 10 contact info |
DK (Aalborg) | participant | 713˙000.00 |
| 8 |
TUTECH INNOVATION GMBH
Organization address
address: Harburger Schlossstrasse 6-12 contact info |
DE (HAMBURG) | participant | 701˙770.00 |
| 9 |
UNIVERSITAET ZUERICH
Organization address
address: Raemistrasse 71 contact info |
CH (ZURICH) | participant | 601˙024.00 |
| 10 |
TECHNISCHE UNIVERSITAET HAMBURG-HARBURG
Organization address
address: SCHWARZENBERGSTRASSE 95 contact info |
DE (HAMBURG) | participant | 561˙212.40 |
| 11 |
PETER BREHM
Organization address
address: AM MUHLBERG 30 contact info |
DE (WEISENDORF) | participant | 479˙999.60 |
| 12 |
WILHELM SCHULTHESS STIFTUNG
Organization address
address: LENGGHALDE 2 contact info |
CH (ZURICH) | participant | 261˙300.00 |
| 13 |
THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST
Organization address
address: ST JAMES'S UNIVERSITY HOSPITAL, BECKETT STREET contact info |
UK (LEEDS) | participant | 213˙263.20 |
| 14 |
AESCULAP AG
Organization address
address: AM AESCULAP PLATZ contact info |
DE (TUTTLINGEN) | participant | 197˙750.00 |
| 15 |
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD contact info |
UK (LONDON) | participant | 172˙568.30 |
Mappa
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Obiettivo del progetto (Objective)
'Articulating joint replacements represent a medical market exceeding €14 billion p.a. that is expected to rise as demographics reflect an ageing population. However, faster growth has been seen in the revision market, where prosthetic joints are replaced, than in primary interventions. The major cause of these revisions is that all joint replacements are prone to wear leading to loss of implant function. Further, it has been demonstrated that adverse or extreme loading has a detrimental effect on implant performance. Thus, device failure still occurs too frequently leading to the conclusion that their longevity and reliability must be improved. The premise of this proposal is to realise that wear and corrosion are an inevitable consequence of all implant interfaces within contemporary total joint replacements. To overcome this problem our novel approach is to use silicon nitride coatings in which the combined high wear resistance of this material and solubility of any silicon nitride wear particles released, reduce the overall potential for adverse tissue reactions. In this work a variety of silicon nitride based coatings will be applied to different tribological scenarios related to total hip arthroplasty. The coatings’ suitability in each scenario will be assessed against target profiles. In particular, it is important to consider coating performance within each of these applications under adverse conditions as well as those outlined in internationally utilised standards. To accomplish this, cutting-edge adverse simulation techniques, in vitro assays and animal models will be developed together with a suite of computational assessments to significantly enhance device testing in terms of predicting clinical performance. Data will inform new standards development and enhance current testing scenarios, and will provide 5 European enterprises with a significant market advantage, whilst providing data for a regulatory submission which is aligned with Dir 93/42/EEC.'
Introduzione (Teaser)
Joint replacement procedures constitute a medical market calculated in billions per year, increasing with the ageing population. As joint replacements are prone to wear, leading to loss of implant function, it is important to extend their lifetime to avoid repeated surgeries.