BIOSIGHET

Exploring the biological significance of phenotypic heterogeneity in Pseudomonas

 Coordinatore EIDGENOESSISCHE ANSTALT FUR WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ 

 Organization address address: UEBERLANDSTRASSE 133
city: DUEBENDORF
postcode: 8600

contact info
Titolo: Ms.
Nome: Laura
Cognome: Klein
Email: send email
Telefono: +41 58 765 5388

 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 192˙622 €
 EC contributo 192˙622 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-04-01   -   2016-01-12

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE ANSTALT FUR WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ

 Organization address address: UEBERLANDSTRASSE 133
city: DUEBENDORF
postcode: 8600

contact info
Titolo: Ms.
Nome: Laura
Cognome: Klein
Email: send email
Telefono: +41 58 765 5388

CH (DUEBENDORF) coordinator 192˙622.20

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 Word cloud

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phenotypic    heterogeneity    hypothesis    hypotheses    direct    labour    significance    phenomenon    population    microbes    experiments    biological    empirical   

 Obiettivo del progetto (Objective)

'Phenotypic heterogeneity – physical diversity amongst genetically identical individuals exposed to the same environmental conditions – is a phenomenon that has caught the interest of biologists for decades. Although recent technological advances have revolutionised our understanding of the mechanistic bases of phenotypic heterogeneity, its adaptive significance and associated biological function(s) remain largely obscure. Two hypotheses have been proffered: (i) the “bet hedging” hypothesis, which postulates that phenotypic heterogeneity is a risk-spreading strategy facilitating population survival in uncertain environments, and (ii) the “division of labour” hypothesis, which proposes that phenotypic heterogeneity can increase population efficiency by partitioning labour (or resources). However, despite great interest in this area, empirical evidence for the biological significance of phenotypic heterogeneity is severely lacking. Here, I propose a series of experiments that combine molecular genetics, state of the art single cell analysis techniques and metabolomics to directly test the biological significance of a recently characterised example of phenotypic heterogeneity: ON/OFF colanic acid capsule expression in the bacterial model system Pseudomonas fluorescens SBW25. By providing a direct, experimental test of hitherto theoretical hypotheses, the proposed experiments have the potential to provide some of the first empirical insight into why phenotypic heterogeneity is such a widespread phenomenon. In addition to being of academic interest, our results will have direct relevance for industries involved in the management of infectious microbes (public health, veterinary science and agriculture) and the use of microbes in product manufacture (biotechnology) and toxin breakdown (bioremediation).'

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