NEURO-COMM

Inter-areal cortical communication: investigating the relationship between hemodynamic and electrophysiological measurements

Coordinatore	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH    more  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Nicole Cognome: Wenderoth Email: send email Telefono: +41 44 635 61 57
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2012-CIG
Funding Scheme	MC-CIG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-06-01   -   2017-05-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Nicole Cognome: Wenderoth Email: send email Telefono: +41 44 635 61 57	CH (ZUERICH)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Perception, cognition and behaviour are achieved through the coordination of multiple brain regions, which exchange information between each other. Large-scale functional interactions arise at two distinct but potentially related temporal scales: “slow” hemodynamic fluctuations measured with functional magnetic resonance imaging (fMRI); and “fast” electrophysiological oscillations of the neurons, as measured non-invasively by electroencephalography (EEG) and magnetoencephalography, and invasively at finer spatial scales by local field potentials and multi-unit activity. Despite enormous recent progress, our understanding of the relationship between, and functional role of fast and slow synchronization in inter-areal cortical communication is still limited. In this project, we will study interactions in large-scale functional networks of healthy human volunteers using combined electrophysiological and hemodynamic measures. We will characterize functional brain networks showing coherent hemodynamic activity at rest and examine how the functional architecture of these networks varies with active behaviour. Moreover, we will study large-scale interactions at different spatio-temporal scales, relating slow fMRI fluctuations with fast EEG oscillations recorded simultaneously. Finally, we will target specific areas under different states by transcranial magnetic stimulation to investigate the causal effects of these focal perturbations on the spatial and temporal properties of brain networks. These studies will provide deeper insights into the mechanisms underlying inter-areal cortical communication and their functional role with respect to behaviour.'