REACH

bioREACtor for stem cell tHerapy

Coordinatore	ACADEMISCH ZIEKENHUIS LEIDEN    more  Organization address address: Albinusdreef 2 city: LEIDEN postcode: 2333 ZA contact info Titolo: Dr. Nome: Brigitte Cognome: Wieles Email: send email Telefono: +3171 5263413
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	6˙790˙994 €
EC contributo	5˙012˙127 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2013-INNOVATION-2
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-07-01   -   2016-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ACADEMISCH ZIEKENHUIS LEIDEN  Organization address address: Albinusdreef 2 city: LEIDEN postcode: 2333 ZA contact info Titolo: Dr. Nome: Brigitte Cognome: Wieles Email: send email Telefono: +3171 5263413	NL (LEIDEN)	coordinator	1˙123˙915.20
2	XPAND BIOTECHNOLOGY BV  Organization address address: PROFESSOR BRONKHORSTLAAN 10D city: BILTHOVEN postcode: 3723 MB contact info Titolo: Prof. Nome: Joost Cognome: De Bruijn Email: send email Telefono: +3130 2297280	NL (BILTHOVEN)	participant	2˙365˙211.80
3	PRESENS PRECISION SENSING GMBH  Organization address address: Josef Engert Strasse 9 city: Regensburg postcode: 93053 contact info Titolo: Dr. Nome: Gernot Cognome: John Email: send email Telefono: +49 94194272109 Fax: +49 941 94272111	DE (Regensburg)	participant	1˙044˙640.40
4	ABER INSTRUMENTS LIMITED  Organization address address: SCIENCE PARK UNIT 5 CEFN LLAN city: ABERSYSTWYTH postcode: SY23 3AH contact info Titolo: Mr. Nome: Matthew Cognome: Lee Email: send email Telefono: +44 1970636300 Fax: +44 1970 615455	UK (ABERSYSTWYTH)	participant	478˙359.72

Mappa

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 Obiettivo del progetto (Objective)

'The REACH-project is a direct result of the FP7 StemExpand project, which aimed at the expansion and engraftment of hematopoietic and mesenchymal stem cells (MSC) for clinical use. The results of these research activities show that a novel, closed and controlled bioreactor can be developed to grow clinically relevant numbers (>400 million) of MSCs. XPand Biotechnology BV(NL) [bioreactor development, technology valorization], Aber Instruments ltd (UK)[biomass sensor] and PreSens Precision Sensing GmbH (GE) [DO, pH sensor] are three SMEs that have teamed up to develop this novel bioreactor system to a pre-commercial scale. The overall aim of the REACH project is to further develop and engineer the bioreactor (incl. valorization, testing and technical and biological validation) to a closed-system sensor-controlled bioreactor with sampling possibilities that allows for GMP-grade MSC production outside a cleanroom. The system will contain a disposable bioreactor bag with unique miniaturized disposable sensors. The DO and pH sensors use optical chemical methods capable of high frequency sampling, this ensures an enhanced stability of the expansion process. Using an expandable bioreactor the volume can be increased during cell culture, without the need for passaging of the cells. Because of this feature the system can be truly closed, without the limitations of a fixed culture substrate area. Leiden University Medical Center (NL) will validate the system and the products in a clinical setting by comparing bioreactor-expanded MSCs with GMP grade MSCs produced by established protocols in the LUMC. Successful development of this bioreactor system will be beneficial for the participating SMEs as well as the medical sector which will be able to develop cell therapies in a faster, cheaper and more efficient way. Collectively, the partners in REACH will develop an exploitation and business plan for the successful valorization of the research done in the FP7 StemExpand project.'