TM-REST

A new platform for fast molecular detection of MDR and XDR resistant strains of M. tuberculosis and of drug resistant malaria

Coordinatore	FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR    more  Organization address address: Via Olgettina 60 city: MILANO postcode: 20132 contact info Titolo: Dr. Nome: Maria Rosa Cognome: Pedrazzi Email: send email Telefono: -26434808 Fax: -26433744
Nazionalità Coordinatore	Italy [IT]
Totale costo	4˙072˙768 €
EC contributo	2˙983˙207 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-01-01   -   2011-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR  Organization address address: Via Olgettina 60 city: MILANO postcode: 20132 contact info Titolo: Dr. Nome: Maria Rosa Cognome: Pedrazzi Email: send email Telefono: -26434808 Fax: -26433744	IT (MILANO)	coordinator	0.00
2	"SPITALI UNIVERSITAR I SEMUNDJEVE TE MUSHKERIVE ""SHEFQET NDROQI"""  Organization address address: "SPITALI UNIVERSITAR I SEMUNDJEVE TE MUSHKERIVE ""SHEFQET NDROQI""" city: TIRANA postcode: 1742 contact info Titolo: Dr. Nome: Rezart Cognome: Oketa Email: send email Telefono: +355 4 354 792 Fax: +355 4 354 792	AL (TIRANA)	participant	0.00
3	FORSCHUNGSZENTRUM BORSTEL  Organization address address: Parkallee 1-40 city: BORSTEL postcode: 23845 contact info Titolo: Ms. Nome: Susann Cognome: Schrader Email: send email Telefono: +49-4537-188.220 Fax: 49-4537-188.731	DE (BORSTEL)	participant	0.00
4	FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS  Organization address address: Avenue Louis-Casai 71 city: COINTRIN GENEVE postcode: 1216 contact info Titolo: Dr. Nome: Herbert Cognome: Clemens Email: send email Telefono: + 41 22 710 05 90 Fax: + 41 22 710 05 99	CH (COINTRIN GENEVE)	participant	0.00
5	NATIONAL CENTER OF INFECTIOUS AND PARASITIC DISEASES  Organization address address: blvd. Yanko Sakazov 26 city: SOFIA postcode: 1504 contact info Titolo: Prof. Nome: Bogdan Cognome: Petrunov Email: send email Telefono: +359 2 944 28 75 Fax: +359 2 943 30 75	BG (SOFIA)	participant	0.00
6	QUEEN MARY UNIVERSITY OF LONDON  Organization address address: 327 MILE END ROAD city: LONDON postcode: E1 4NS contact info Titolo: Ms. Nome: Warren Cognome: Lindsey Email: send email Telefono: +44 207 882 7264 Fax: +44 207 882 7276	UK (LONDON)	participant	0.00
7	STMICROELECTRONICS SRL  Organization address address: VIA C.OLIVETTI 2 city: AGRATE BRIANZA postcode: 20864 contact info Titolo: Dr. Nome: Maria Cristina Cognome: Di Gesù Email: send email Telefono: -7408362 Fax: -7407569	IT (AGRATE BRIANZA)	participant	0.00
8	UNIVERSITA' DEGLI STUDI DI SIENA  Organization address address: VIA BANCHI DI SOTTO 55 city: SIENA postcode: 53100 contact info Titolo: Prof. Nome: Silvano Cognome: Focardi Email: send email Telefono: -232744 Fax: -232740	IT (SIENA)	participant	0.00
9	UNIVERSITY OF GLASGOW  Organization address address: University Avenue city: GLASGOW postcode: G12 8QQ contact info Titolo: Mr. Nome: Joseph Cognome: Galloway Email: send email Telefono: +44 141 330 3884 Fax: +44 141 330 5611	UK (GLASGOW)	participant	0.00

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 Obiettivo del progetto (Objective)

'Recent developments in molecular tools combined with updated epidemiological data provide novel challenges to the development of modern molecular diagnostics. The increasing threat of infections due to Mycobacterium tuberculosis, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections poses important questions that call for development of integrated tools for rapid diagnosis. In the specific case of tuberculosis (TB), an integrated rapid diagnostic approach should be able to allow at the same time species identification, drug susceptibility testing and molecular typing. We propose to develop and validate a silicon-based platform for molecular biology testing consisting in a single disposable device (biochip) and on associated specific instruments (reader). This technology is able to simultaneously serve as a platform for high specificity amplification and hybridisation of selected targets, and to provide the diagnostic report within few hours. Main advancement over existing technology (i.e. Real-Time PCR) consists in the possibility to perform the test at competitive costs, using an higher number of genetic probes by integrating multiple, separate PCR chambers and medium density array (50-200 probes), with faster and more stable amplification and hybridisation reactions through optimised and controlled thermal ramps and profile. In addition to the technology development, special focus will be put on the feasibility and cost-effectiveness of such a novel tool with high technological content for application in countries with high TB, MDR- and XDR-TB incidence. In parallel to the development and validation of the chip-based diagnostic platform for TB, a feasibility study on its applicability to other poverty related diseases such as malaria, will be carried out. In summary, the present proposal aims at developing an affordable, high-tech platform for rapid molecular diagnosis applicable to TB and other infectious and poverty-related diseases'