NEUROSCAFFOLDS

Rapid prototyping scaffolds for the nervous system

Coordinatore	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI    more  Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Mr. Nome: Gabriele Cognome: Rizzetto Email: send email Telefono: +39 0403787201 Fax: +39 040 3787249
Nazionalità Coordinatore	Italy [IT]
Totale costo	2˙321˙776 €
EC contributo	1˙799˙788 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2013-EU-China
Funding Scheme	CP-FP
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-07-01   -   2016-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI  Organization address address: VIA BONOMEA 265 city: TRIESTE postcode: 34136 contact info Titolo: Mr. Nome: Gabriele Cognome: Rizzetto Email: send email Telefono: +39 0403787201 Fax: +39 040 3787249	IT (TRIESTE)	coordinator	486˙600.00
2	LUNDS UNIVERSITET  Organization address address: Paradisgatan 5c city: LUND postcode: 22100 contact info Titolo: Prof. Nome: Jens Cognome: Schouenborg Email: send email Telefono: 46462227752	SE (LUND)	participant	404˙998.00
3	ECOLE NORMALE SUPERIEURE  Organization address address: "45, RUE D'ULM" city: PARIS CEDEX 05 postcode: 75230 contact info Titolo: Mrs. Nome: Anne Cognome: Cormier Email: send email Telefono: +33 1 44 32 31 91 Fax: +33 1 44 32 20 99	FR (PARIS CEDEX 05)	participant	404˙880.00
4	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA  Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 contact info Titolo: Ms. Nome: Claudia Cognome: Schiaffino Email: send email Telefono: +39 0107178757 Fax: +39 01071781230	IT (GENOVA)	participant	353˙310.00
5	UNIVERSITA DEGLI STUDI DI TRIESTE  Organization address address: PIAZZALE EUROPA 1 city: TRIESTE postcode: 34127 contact info Titolo: Dr. Nome: Paolo Cognome: Balsini Email: send email Telefono: 390406000000 Fax: 390406000000	IT (TRIESTE)	participant	150˙000.00

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 Obiettivo del progetto (Objective)

'Advanced tissue engineering requires scaffolds fabricated at different scales to facilitate cellular repair. Neurons respond to micro and nanopatterns over which are grown and it is possible to control - to some extent - neurite protrusion and the formation of neuronal network by using only nanopatterns. The present proposal is based on four main steps: i - Development and fabrication of Scaffolds; ii - Experimentation and testing of the formation of 3D neuronal networks; iii - Analysis of long term survival of 3D neuronal networks; iv- Development and testing of scaffolds for implants. The final and most important step concerns the implantation of our scaffolds in a neuronal tissue for repair. We will attempt to implant our scaffolds for repairing spinal cord and sciatic nerve injuries, a realistic but challenging aim. Controlled nanoscaled scaffolds will be obtained using nanocomposite materials to obtain custom-designed SFF scaffolds. These scaffolds will be constructed with different materials and will be decorated with appropriate CNTs and/or signaling molecules. Medical imaging will be used to target and interface personalized scaffold production for repair of injuries of the spinal cord and sciatic nerve. In order to achieve these results we have formed a collaboration based on two clusters of research centres, one in China and one in Europe. The cluster in China is composed of the Chinese Academy of Science in Bejing, the Institute of NanoTech and NanoBionics in Suzhou and the Department of Neurosurgery Neurology, Drum Tower Hospital, of the Nanjing University. The cluster in Europe is formed by SISSA in Trieste, the University of Trieste, IIT in Genova, Ecole Normale Supérieure (ENS) in Paris and the University of Lund in Sweden where the repair of the sciatic nerve and the spinal cord will be studied. These two clusters have all the expertise to tackle and reach our objectives.'