NR-NET

Control of metabolic and inflammatory pathways by nuclear receptors

Coordinatore	BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING    more  Organization address address: Al. Fleming Street 34 city: VARI-ATHENS postcode: 16672 contact info Titolo: Dr. Nome: Iannis Cognome: Talianidis Email: send email Telefono: 302110000000 Fax: +30 210 965 65663
Nazionalità Coordinatore	Greece [EL]
Totale costo	3˙971˙184 €
EC contributo	3˙971˙184 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-ITN
Funding Scheme	MC-ITN
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2017-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING  Organization address address: Al. Fleming Street 34 city: VARI-ATHENS postcode: 16672 contact info Titolo: Dr. Nome: Iannis Cognome: Talianidis Email: send email Telefono: 302110000000 Fax: +30 210 965 65663	EL (VARI-ATHENS)	coordinator	757˙301.02
2	UNIVERSITE DE LAUSANNE  Organization address city: LAUSANNE postcode: 1015 contact info Titolo: Prof. Nome: Beatrice Cognome: Desvergne Email: send email Telefono: +41 216924140 Fax: +41 216924115	CH (LAUSANNE)	participant	540˙631.52
3	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Mr. Nome: Thomas Cognome: Tinglöv Email: send email Telefono: 46852483549	SE (STOCKHOLM)	participant	504˙297.20
4	UNIVERSITY OF LEICESTER  Organization address address: University Road city: LEICESTER postcode: LE1 7RH contact info Titolo: Mrs. Nome: Marie Cognome: Adams Email: send email Telefono: +44 116 223 1799 Fax: +44 116 252 2028	UK (LEICESTER)	participant	481˙694.40
5	UNIVERSITA DEGLI STUDI DI BARI ALDO MORO  Organization address address: Piazza Umberto I 1 city: BARI postcode: 70121 contact info Titolo: Dr. Nome: Francesca Cognome: Vadacca Email: send email Telefono: 390805000000 Fax: +39 0805478778	IT (BARI)	participant	407˙996.60
6	DEBRECENI EGYETEM  Organization address address: EGYETEM TER 1 city: DEBRECEN postcode: 4032 contact info Titolo: Prof. Nome: Laszlo Cognome: Nagy Email: send email Telefono: 36303824755	HU (DEBRECEN)	participant	390˙193.76
7	CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE  Organization address address: Rue Laurent Fries 1 city: ILLKIRCH GRAFFENSTADEN postcode: 67404 contact info Titolo: Dr. Nome: Steve Cognome: Brooks Email: send email Telefono: +33 3 88 65 33 94	FR (ILLKIRCH GRAFFENSTADEN)	participant	262˙548.66
8	UNIVERSITA DEGLI STUDI DI MILANO  Organization address address: Via Festa Del Perdono 7 city: MILANO postcode: 20122 contact info Titolo: Mr. Nome: Sergio Cognome: Longo Email: send email Telefono: +39 02 50318335 Fax: +39 02 50318391	IT (MILANO)	participant	247˙437.96
9	DIAGENODE  Organization address address: RUE DU BOIS SAINT JEAN 3 LIEGE PARK SCIENCE city: SERAING postcode: 4102 contact info Titolo: Dr. Nome: Helene Cognome: Pendeville Email: send email Telefono: 3243642061 Fax: +32 43642051	BE (SERAING)	participant	205˙260.00
10	UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT  Organization address address: NAGYERDEI KRT 98 city: DEBRECEN postcode: 4032 contact info Titolo: Dr. Nome: Gabor Cognome: Zahuczky Email: send email Telefono: +3630 4946496 Fax: +3652 314372	HU (DEBRECEN)	participant	173˙822.88

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic inflammation – is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several nuclear receptors can directly sense metabolic alterations, we propose that they could be considered as important endogenous modulators of metaflammatory pathways further expanding the repertoire of diseases that can be intervened by NR-modulating drugs. NR-NET is expected to deliver important new knowledge on the basic biological processes involved in the mechanism of epigenetic control of gene expression by nuclear receptors, on structural and functional aspects of nuclear receptor action with an ultimate goal of better understanding the pathogenesis of metabolic disorders and inflammation. The composition of the network was designed to contain a balanced mix of labs with experience and skills in academic and industry based research, so that it can provide young researchers the opportunity to acquire skills and expertise in: a. Structural and functional aspects of NR-regulated gene expression b. Genomics and proteomics approaches to analyze complex regulatory networks c. Systems biology approaches and bioinformatics tools to define composite regulatory modules d. Studying metabolic and inflammatory pathways in model organisms The research will be conducted under the framework of a structured training program, which includes a myriad of Individual and Network-wide training activities. Apart from training in academic and industry-based research projects, specific emphasis will be given to training in transferable skills and the stimulation of creativity and entrepreneurial mindset of researchers.'