SHOCKOMICS

MULTISCALE APPROACH TO THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN ACUTE HEART FAILURE INDUCED BY SHOCK

 Coordinatore POLITECNICO DI MILANO 

 Organization address address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133

contact info
Titolo: Dr.
Nome: Fabio
Cognome: Conti
Email: send email
Telefono: +39 02 23993431
Fax: +39 02 23993417

 Nazionalità Coordinatore Italy [IT]
 Sito del progetto http://www.shockomics.org
 Totale costo 6˙729˙586 €
 EC contributo 5˙174˙001 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2017-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO

 Organization address address: PIAZZA LEONARDO DA VINCI 32
city: MILANO
postcode: 20133

contact info
Titolo: Dr.
Nome: Fabio
Cognome: Conti
Email: send email
Telefono: +39 02 23993431
Fax: +39 02 23993417

IT (MILANO) coordinator 868˙837.00
2    CUSTOM SOFTWARE & ELECTRONICS SL

 Organization address address: C/MARIE CURIE SN - PARC TEC BARNA N
city: BARCELONA
postcode: 8042

contact info
Titolo: Dr.
Nome: Ramon
Cognome: Domenech
Email: send email
Telefono: +34 93 3534032

ES (BARCELONA) participant 791˙380.00
3    FILARETE SERVIZI SRL

 Organization address address: VIALE ORTLES 22 4
city: MILANO MI
postcode: 20139

contact info
Titolo: Dr.
Nome: Barbara
Cognome: Martini
Email: send email
Telefono: +39 02 56660163

IT (MILANO MI) participant 788˙070.00
4    NEURO-ZONE SRL

 Organization address address: VIA PODGORA 7
city: MILANO
postcode: 20122

contact info
Titolo: Dr.
Nome: Valentina
Cognome: Cartareggia
Email: send email
Telefono: +39 02 56660212
Fax: +39 0254124217

IT (MILANO) participant 477˙400.00
5    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Mr.
Nome: Enzo
Cognome: Fancello
Email: send email
Telefono: +41 2 23727408
Fax: +41 2 23727413

CH (GENEVE) participant 447˙000.00
6    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

 Organization address address: Via Giuseppe La Masa 19
city: MILANO
postcode: 20156

contact info
Titolo: Ms.
Nome: Maria Grazia
Cognome: Pezzoni
Email: send email
Telefono: 390239000000
Fax: 39023546277

IT (MILANO) participant 441˙401.00
7    FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA

 Organization address address: Baldiri i Reixac, 10-12
city: BARCELONA
postcode: 8028

contact info
Titolo: Mr.
Nome: Moises
Cognome: Tarte
Email: send email
Telefono: 34934037036

ES (BARCELONA) participant 393˙000.00
8    ANTLIA SA

 Organization address address: PARC SCIENTIFIQUE EPFL PSE C ECLUBLENS PSE
city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Nikolaos
Cognome: Stergiopulos
Email: send email
Telefono: +41 21 6938346

CH (LAUSANNE) participant 290˙000.00
9    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

 Organization address address: "FRANKLIN STREET 1111, 12 FLOOR"
city: OAKLAND CA
postcode: 94607

contact info
Titolo: Mr.
Nome: Cortlandt
Cognome: Urquhart
Email: send email
Telefono: +1 858 5340244
Fax: +1 858 5340280

US (OAKLAND CA) participant 282˙705.00
10    UNIVERSITE LIBRE DE BRUXELLES

 Organization address address: Avenue Franklin Roosevelt 50
city: BRUXELLES
postcode: 1050

contact info
Titolo: Dr.
Nome: Christine
Cognome: Courillon
Email: send email
Telefono: +32 2 6506718
Fax: +32 2 6502321

BE (BRUXELLES) participant 267˙848.00
11    MUTUA DE TERRASSA MUTUALITAT DE PREVISIO SOCIAL A PRIMA FIXA

 Organization address address: PLAZA DR ROBERT 5
city: TERRASSA
postcode: 8221

contact info
Titolo: Ms.
Nome: Laura
Cognome: Buguñá Hoffmann
Email: send email
Telefono: +34 93 73650501174
Fax: +34 93 7367011

ES (TERRASSA) participant 126˙360.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

stability    organ    fluid    care    overcome    multiple    shock    molecular    therapies    patients   

 Obiettivo del progetto (Objective)

'The management of cardiovascular stability in shock patients is of paramount importance in critical care. New, cutting edge knowledge is necessary to overcome the shortcomings of available therapies, in order to cope with the challenges that anesthesiologists, intensive care specialists and emergency physicians face when dealing with shock patients. Current therapies are targeted to reduce symptoms of shock and multiple organ failure, but they are unable to target the root cause or to act at the “beginning of the cascade”, because of the lack of a model explaining the molecular basis of shock induced tissue injury and ensuing multiple organ failure. Hence, the effectiveness of anti-hypotensive interventions such as fluid resuscitation is limited. Fluid may restore blood pressure within minutes, but complications such as pulmonary edema may arise on a longer time scale in patients who are unresponsive to fluid infusion, and cause more severe stress to the patient’s hemodynamic stability, respiratory efficiency, and immune system. This proposal seeks to shed light on the molecular trigger of acute heart failure in association to shock, in the presence of uncontrolled proteolytic activity, in order to identify inflammatory mediators and markers which are activated in shock, through a systematic analysis of expression levels of genes and their protein products, and novel targets for the delivery of new therapies, necessary to overcome the limitations of current ones.'

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