SHOCKOMICS
MULTISCALE APPROACH TO THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN ACUTE HEART FAILURE INDUCED BY SHOCK
| Coordinatore | POLITECNICO DI MILANO
Organization address
address: PIAZZA LEONARDO DA VINCI 32 contact info |
| Nazionalità Coordinatore | Italy [IT] |
| Sito del progetto | http://www.shockomics.org |
| Totale costo | 6˙729˙586 € |
| EC contributo | 5˙174˙001 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-10-01 - 2017-09-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
POLITECNICO DI MILANO
Organization address
address: PIAZZA LEONARDO DA VINCI 32 contact info |
IT (MILANO) | coordinator | 868˙837.00 |
| 2 |
CUSTOM SOFTWARE & ELECTRONICS SL
Organization address
address: C/MARIE CURIE SN - PARC TEC BARNA N contact info |
ES (BARCELONA) | participant | 791˙380.00 |
| 3 |
FILARETE SERVIZI SRL
Organization address
address: VIALE ORTLES 22 4 contact info |
IT (MILANO MI) | participant | 788˙070.00 |
| 4 |
NEURO-ZONE SRL
Organization address
address: VIA PODGORA 7 contact info |
IT (MILANO) | participant | 477˙400.00 |
| 5 |
UNIVERSITE DE GENEVE
Organization address
address: Rue du General Dufour 24 contact info |
CH (GENEVE) | participant | 447˙000.00 |
| 6 |
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Organization address
address: Via Giuseppe La Masa 19 contact info |
IT (MILANO) | participant | 441˙401.00 |
| 7 |
FUNDACIO PRIVADA PARC CIENTIFIC DE BARCELONA
Organization address
address: Baldiri i Reixac, 10-12 contact info |
ES (BARCELONA) | participant | 393˙000.00 |
| 8 |
ANTLIA SA
Organization address
address: PARC SCIENTIFIQUE EPFL PSE C ECLUBLENS PSE contact info |
CH (LAUSANNE) | participant | 290˙000.00 |
| 9 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Organization address
address: "FRANKLIN STREET 1111, 12 FLOOR" contact info |
US (OAKLAND CA) | participant | 282˙705.00 |
| 10 |
UNIVERSITE LIBRE DE BRUXELLES
Organization address
address: Avenue Franklin Roosevelt 50 contact info |
BE (BRUXELLES) | participant | 267˙848.00 |
| 11 |
MUTUA DE TERRASSA MUTUALITAT DE PREVISIO SOCIAL A PRIMA FIXA
Organization address
address: PLAZA DR ROBERT 5 contact info |
ES (TERRASSA) | participant | 126˙360.00 |
Mappa
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Obiettivo del progetto (Objective)
'The management of cardiovascular stability in shock patients is of paramount importance in critical care. New, cutting edge knowledge is necessary to overcome the shortcomings of available therapies, in order to cope with the challenges that anesthesiologists, intensive care specialists and emergency physicians face when dealing with shock patients. Current therapies are targeted to reduce symptoms of shock and multiple organ failure, but they are unable to target the root cause or to act at the “beginning of the cascade”, because of the lack of a model explaining the molecular basis of shock induced tissue injury and ensuing multiple organ failure. Hence, the effectiveness of anti-hypotensive interventions such as fluid resuscitation is limited. Fluid may restore blood pressure within minutes, but complications such as pulmonary edema may arise on a longer time scale in patients who are unresponsive to fluid infusion, and cause more severe stress to the patient’s hemodynamic stability, respiratory efficiency, and immune system. This proposal seeks to shed light on the molecular trigger of acute heart failure in association to shock, in the presence of uncontrolled proteolytic activity, in order to identify inflammatory mediators and markers which are activated in shock, through a systematic analysis of expression levels of genes and their protein products, and novel targets for the delivery of new therapies, necessary to overcome the limitations of current ones.'
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