TRANSPORET

Transmembrane Molecular Machines

Coordinatore	THE UNIVERSITY OF EDINBURGH    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	1˙499˙780 €
EC contributo	1˙499˙780 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-StG
Funding Scheme	ERC-SG
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-09-01   -   2018-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN  Organization address address: Oude Markt 13 city: LEUVEN postcode: 3000 contact info Titolo: Dr. Nome: Elke Cognome: Lammertyn Email: send email Telefono: +32 16 32 06 21	BE (LEUVEN)	beneficiary	30˙000.00
2	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Dr. Nome: Scott Cognome: Cockroft Email: send email Telefono: +44 131 650 4758 Fax: +44 131 650 6453	UK (EDINBURGH)	hostInstitution	1˙469˙780.00
3	THE UNIVERSITY OF EDINBURGH  Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL contact info Titolo: Ms. Nome: Angela Cognome: Noble Email: send email Telefono: +44 131 650 9024 Fax: +44 131 651 9024	UK (EDINBURGH)	hostInstitution	1˙469˙780.00

Mappa

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 Obiettivo del progetto (Objective)

'This research programme is dedicated to the development of rationally designed transmembrane molecular machines. Proteins that undergo nanomechanical transitions to facilitate transmembrane communication, or that operate as transmembrane pumps, rotary motors, and molecular transporters are ubiquitous in nature. Despite much progress in the development of solid-state and chemical nanomechanical devices such as molecular rotors, walkers and logic devices, no such systems have been developed that operate across lipid membranes.

Thus, by exploiting our knowledge of biological and synthetic supramolecular components we seek to construct some of the first ever transmembrane molecular machines built to man-made specifications. Mirroring the operation of biological transmembrane molecular machines, compartmentalisation facilitates the construction of nanomechanical devices that can be driven by electrochemical gradients, or those that operate in the reverse sense by turning over chemical fuels to establish non-equilibrium conditions. We intend to demonstrate these principles by combining nanopore-based techniques and DNA-recognition processes to assemble a range of membrane-spanning nanomechanical devices that can be operated, controlled and monitored down to single-molecule levels:

Project 1 – Transmembrane logic & signalling on the single-molecule level. Project 2 – A transmembrane transporter. Project 3 – A transmembrane reciprocating pump. Project 4 – A transmembrane rotary motor.'