DISCHARGE
Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies
| Coordinatore | CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Organization address
address: Chariteplatz 1 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.dischargetrial.eu |
| Totale costo | 7˙695˙860 € |
| EC contributo | 5˙999˙995 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2013-INNOVATION-1 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2014 |
| Periodo (anno-mese-giorno) | 2014-02-01 - 2019-01-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Organization address
address: Chariteplatz 1 contact info |
DE (BERLIN) | coordinator | 1˙908˙112.00 |
| 2 |
PAULA STRADINA KLINISKA UNIVERSITATES SLIMNICA AS
Organization address
address: PILSONU IELA 13 contact info |
LV (RIGA) | participant | 282˙424.00 |
| 3 |
FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS
Organization address
address: PLAZA ASUA 1 contact info |
ES (SONDIKA) | participant | 234˙000.00 |
| 4 |
UNIVERSITAIR ZIEKENHUIS ANTWERPEN
Organization address
address: WILRIJKSTRAAT 10 contact info |
BE (EDEGEM) | participant | 223˙020.00 |
| 5 |
REGION HOVEDSTADEN
Organization address
address: KONGENS VAENGE 2 contact info |
DK (HILLEROD) | participant | 220˙926.00 |
| 6 |
OSTERGOTLANDS LAN
Organization address
address: Smedstadvagen contact info |
SE (Linkoping) | participant | 220˙708.00 |
| 7 |
KANTONSSPITAL ST. GALLEN
Organization address
address: Rorschacherstrasse 95 contact info |
CH (ST. GALLEN) | participant | 192˙400.00 |
| 8 |
Nome Ente NON disponibile
Organization address
city: Jena contact info |
DE (Jena) | participant | 181˙000.00 |
| 9 |
CESKE VYSOKE UCENI TECHNICKE V PRAZE
Organization address
address: ZIKOVA 4 contact info |
CZ (PRAHA) | participant | 180˙440.00 |
| 10 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Organization address
address: BELFIELD contact info |
IE (DUBLIN) | participant | 169˙920.00 |
| 11 |
SOUTH EASTERN HEALTH AND SOCIAL CARE TRUST NHS
Organization address
address: UPPER NEWTOWNARDS ROAD ULSTER contact info |
UK (BELFAST) | participant | 167˙640.00 |
| 12 |
MEDIZINISCHE UNIVERSITAET INNSBRUCK
Organization address
address: Christoph-Probst Platz 1 contact info |
AT (INNSBRUCK) | participant | 160˙064.00 |
| 13 |
ACADEMISCH ZIEKENHUIS LEIDEN
Organization address
address: Albinusdreef 2 contact info |
NL (LEIDEN) | participant | 157˙240.00 |
| 14 |
INSTITUT CATALA DE LA SALUT
Organization address
address: GRAN VIA DE LES CORTS CATALANES 587 contact info |
ES (BARCELONA) | participant | 155˙080.00 |
| 15 |
AINTREE UNIVERSITY HOSPITAL NHS FOUNDATION TRUST
Organization address
address: LONGMOOR LANE contact info |
UK (LIVERPOOL) | participant | 152˙560.00 |
| 16 |
SEMMELWEIS EGYETEM
Organization address
address: Ulloi ut 26 contact info |
HU (BUDAPEST) | participant | 140˙520.00 |
| 17 |
ALB FILS KLINIKEN GMBH
Organization address
address: EICHERTSTRASSE 3 contact info |
DE (GOPPINGEN) | participant | 136˙696.00 |
| 18 |
UNIVERSITAET LEIPZIG
Organization address
address: RITTERSTRASSE 26 contact info |
DE (LEIPZIG) | participant | 136˙696.00 |
| 19 |
CENTRO HOSPITALAR DE VILA NOVA DE GAIA/ESPINHO EPE
Organization address
address: RUA CONCEICAO FERNANDES S/N contact info |
PT (VILA NOVA DE GAIA) | participant | 131˙760.00 |
| 20 |
LIETUVOS SVEIKATOS MOKSLU UNIVERSITETAS
Organization address
address: A MICKEVICIAUS GATVE 9 contact info |
LT (KAUNAS) | participant | 118˙960.00 |
| 21 |
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Organization address
address: Piazzale Aldo Moro 5 contact info |
IT (ROMA) | participant | 116˙632.00 |
| 22 |
UNIVERSITA DEGLI STUDI DI CAGLIARI
Organization address
address: VIA UNIVERSITA 40 contact info |
IT (CAGLIARI) | participant | 114˙480.00 |
| 23 |
FAKULTNI NEMOCNICE V MOTOLE
Organization address
address: V UVALU 84 contact info |
CZ (PRAHA 5) | participant | 112˙260.00 |
| 24 |
CARDIO MED SRL
Organization address
address: 22 DECEMBRIE 1989 STRADA 76 AP 1 contact info |
RO (TARGU MURES) | participant | 98˙625.00 |
| 25 |
UNIVERSITY OF GLASGOW
Organization address
address: University Avenue contact info |
UK (GLASGOW) | participant | 96˙400.00 |
| 26 |
WOJEWODZKI SZPITAL SPECJALISTYCZNY WE WROCLAWIU
Organization address
address: UL. HENRYKA MICHALA KAMIENSKIEGO 73 A contact info |
PL (WROCLAW) | participant | 88˙892.00 |
| 27 |
INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE
Organization address
address: PUT DOKTORA GOLDMANA 4 contact info |
RS (SREMSKA KAMENICA) | participant | 70˙860.00 |
| 28 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Organization address
address: 101 Rue de Tolbiac contact info |
FR (PARIS) | participant | 31˙680.00 |
Mappa
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Obiettivo del progetto (Objective)
'Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test for CAD currently available. CT may become the most effective strategy to reduce the ca. 2 million annual negative ICAs in Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD. To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The primary hypothesis will be that CT is superior to ICA for major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) after a maximum follow-up of 4 years in a selected broad population of stable chest pain patients with intermediate pretest likelihood of CAD. The trial will include 23 clinical sites from 18 European countries ensuring broad geographical representation. Comparative effectiveness research of complementing work packages include gender-related analysis, systematic review of evidence, cost-effectiveness analysis, and health-related quality of life. DISCHARGE has the capability to influence current standards and guidelines as well as coverage decisions and will raise awareness among patients, health care providers, and decision-makers in Europe about the effectiveness and cost-effectiveness of coronary CT angiography.'