INDOX
Optimized oxidoreductases for medium and large scale industrial biotransformations
| Coordinatore | AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
| Nazionalità Coordinatore | Spain [ES] |
| Totale costo | 11˙196˙317 € |
| EC contributo | 7˙825˙824 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2013-7-single-stage |
| Funding Scheme | CP-TP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-11-01 - 2016-10-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | coordinator | 2˙048˙325.00 |
| 2 |
TECHNISCHE UNIVERSITEIT DELFT
Organization address
address: Stevinweg 1 contact info |
NL (DELFT) | participant | 592˙075.00 |
| 3 |
WAGENINGEN UNIVERSITY
Organization address
address: DROEVENDAALSESTEEG 4 contact info |
NL (WAGENINGEN) | participant | 575˙993.00 |
| 4 |
TECHNISCHE UNIVERSITAET DRESDEN
Organization address
address: HELMHOLTZSTRASSE 10 contact info |
DE (DRESDEN) | participant | 572˙700.00 |
| 5 |
NOVOZYMES A/S
Organization address
address: Krogshoejvej 36 contact info |
DK (BAGSVAERD) | participant | 516˙921.00 |
| 6 |
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Organization address
address: Rue De L'Universite 147 contact info |
FR (PARIS CEDEX 07) | participant | 496˙677.00 |
| 7 |
UNIVERSITAET FUER BODENKULTUR WIEN
Organization address
address: Gregor Mendel Strasse 33 contact info |
AT (WIEN) | participant | 481˙582.00 |
| 8 |
BIOPOLIS SL
Organization address
address: CALLE CATEDRATICO AGUSTIN ESCARDINO 9 contact info |
ES (PATERNA VALENCIA) | participant | 407˙404.00 |
| 9 |
ANAXOMICS BIOTECH, S.L.
Organization address
address: CALLE BALMES (PISO 4 - PTA 2A) 89 contact info |
ES (Barcelona) | participant | 349˙200.00 |
| 10 |
JENABIOS GMBH: UMWELTBIOTECHNOLOGIEN & SERVICELEISTUNGEN
Organization address
address: Orlaweg 2 contact info |
DE (Jena) | participant | 348˙600.00 |
| 11 |
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II.
Organization address
address: Corso Umberto I 40 contact info |
IT (NAPOLI) | participant | 333˙600.00 |
| 12 |
Setas Kimya Sanayi AS
Organization address
address: Karanfil sok 1.levent 18 contact info |
TR (Istanbul) | participant | 333˙265.00 |
| 13 |
CHIRACON GMBH
Organization address
address: BIOTECHNOLOGIEPARK TGZ 1 contact info |
DE (LUCKENWALDE) | participant | 319˙000.00 |
| 14 |
CLEA TECHNOLOGIES BV
Organization address
address: DELFTECHPARK 34 contact info |
NL (DELFT) | participant | 250˙536.00 |
| 15 |
CHEMINOVA AS
Organization address
address: HARBOOREVEJ 78 contact info |
DK (HARBOORE) | participant | 199˙946.00 |
Mappa
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Obiettivo del progetto (Objective)
The INDOX proposal on industrial oxidoreductases aims to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation reactions to a significant extent primarily due to lack of biocatalysts with the required selectivity, availability and compatibility with the rigorous process conditions. Selected industrial oxidation and oxyfunctionalization target reactions form the basis for the INDOX screening and optimization of new biocatalysts, including: i) Intermediates for agrochemicals/APIs; ii) Polymer precursors and functionalized polymers; and iii) Intermediates for dye-stuffs. The project flow comprises: i) Recovery of selective biocatalysts from the groups of heme-peroxidases/peroxygenases, flavo-oxidases and copper-oxidoreductases from fungal genomes and other sources; ii) Improvement of their oxidative activity and stability by protein engineering (using rational design, directed evolution and hybrid approaches combined with computational calculations) to fulfill the operational and catalytic conditions required by the chemical industry; and iii) Optimization of reaction conditions and reactor configurations (including immobilization technologies and new enzymatic cascade reactions). Finally the cost efficiency compared to chemical processing will be evaluated. The INDOX approach is supported by a highly-specialized consortium of SMEs, large companies and research/academic institutions. Production of the new optimized biocatalysts and their introduction into the chemical market will take advantage from the participation of the world-leading company in the sector of industrial enzymes, together with several chemical companies willing to implement the new medium- and large-scale biotransformation processes.
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