MIRACLE

Novel tumor-selective lethal miRNAs for the treatment of head and neck cancer

Coordinatore	STICHTING VU-VUMC    more  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Mr. Nome: Michel Cognome: Telkamp Email: send email Telefono: 31204448190 Fax: 31204448260
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	1˙522˙769 €
EC contributo	1˙172˙000 €
Programma	FP7-SME Specific Programme "Capacities": Research for the benefit of SMEs
Code Call	FP7-SME-2013
Funding Scheme	BSG-SME
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-10-01   -   2015-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING VU-VUMC  Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV contact info Titolo: Mr. Nome: Michel Cognome: Telkamp Email: send email Telefono: 31204448190 Fax: 31204448260	NL (AMSTERDAM)	coordinator	7˙500.00
2	INTERNA TECHNOLOGIES BV  Organization address address: JONKERBOSPLEIN 52 city: NIJMEGEN postcode: 6534 AB contact info Titolo: Dr. Nome: Jack Cognome: Veuskens Email: send email Telefono: 32496741166	NL (NIJMEGEN)	participant	496˙678.50
3	QUIET THERAPEUTICS LTD  Organization address address: YAKHIN INDUSTRIAL PARK city: ASHKELON postcode: 78172 contact info Titolo: Dr. Nome: Ron Cognome: Lahav Email: send email Telefono: 972550000000 Fax: 97289302878	IL (ASHKELON)	participant	424˙580.00
4	BIOSPRING GESELLSCHAFT FUR BIOTECHNOLOGIE MBH  Organization address address: ALT-FECHENHEIM 34 city: FRANKFURT AM MAIN postcode: 60386 contact info Titolo: Dr. Nome: Jorg Cognome: Hauf Email: send email Telefono: +49 69 4080 7222 Fax: +49 69 4260 3718	DE (FRANKFURT AM MAIN)	participant	228˙241.50
5	LPT LABORATORY OF PHARMACOLOGY AND TOXICOLOGY GMBH & CO KG  Organization address address: REDDERWEG 8 city: HAMBURG postcode: 21147 contact info Titolo: Dr. Nome: Jost Cognome: Leuschner Email: send email Telefono: 4940702020 Fax: 494070000000	DE (HAMBURG)	participant	7˙500.00
6	OCTOPLUS NV  Organization address address: ZERNIKEDREEF 12 city: LEIDEN postcode: 2333 CL contact info Nome: Anton Cognome: Mat Email: send email Telefono: +31 715244676	NL (LEIDEN)	participant	7˙500.00

Mappa

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 Obiettivo del progetto (Objective)

'MiRacle focuses on the development of a therapeutic formulation for the treatment of head and neck cancer. Head and neck cancer contributes to approximately 5% of all cancers in the Western world. Unfortunately the majority of H&N cancer patients present with advanced stages of disease. These patients frequently develop locoregional recurrences, distant metastasis and/or second primary tumors resulting in 5-years survival rates of less than 60% The development of novel anti-cancer agents to improve outcome is therefore urgently awaited.

The goal of MiRacle is the advancement of a therapeutic tumor-killing miRNA formulation towards the clinic by combining two innovative technologies, i.e. therapeutic miRNA and head and neck tumor specific targeted drug delivery. Such a project requires (1) expertise in the therapeutic application of miRNA (InteRNA) and knowledge on the synthesis of biochemical active miRNA (Biospring), (2) expertise in a drug formulation to deliver the therapeutic miRNA into humans (Quiet) and understanding the synthesis of complex drug formulations (Octoplus), plus (3) in depth knowledge of the therapeutic indication, e.g. H&N cancer (VUmc) and skilfulness in toxicity tests that are required for RNA based drug registration (LPT). We believe that this project encompasses all parties that are required to successfully bring a tumor killing miRNA towards registration for first in human testing.'