IMAVALVE

Intelligent materials for in-situ heart Valve tissue engineering

Coordinatore	TECHNISCHE UNIVERSITEIT EINDHOVEN    more  Organization address address: DEN DOLECH 2 city: EINDHOVEN postcode: 5612 AZ contact info Titolo: Mr. Nome: Leon Cognome: Luwijs Email: send email Telefono: 31402474313
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	7˙338˙397 €
EC contributo	5˙652˙133 €
Programma	FP7-NMP Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
Code Call	FP7-NMP-2013-SME-7
Funding Scheme	CP-TP
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-01-01   -   2017-12-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITEIT EINDHOVEN  Organization address address: DEN DOLECH 2 city: EINDHOVEN postcode: 5612 AZ contact info Titolo: Mr. Nome: Leon Cognome: Luwijs Email: send email Telefono: 31402474313	NL (EINDHOVEN)	coordinator	1˙440˙313.00
2	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Prof. Nome: Simon Philipp Cognome: Hoerstrup Email: send email Telefono: +41 442553801	CH (ZURICH)	participant	1˙451˙404.00
3	JENAVALVE TECHNOLOGY GMBH  Organization address address: GUERICKESTRASSE 25 city: MUNCHEN BAYERN postcode: 80805 contact info Titolo: Mr. Nome: Martin Cognome: Schlun Email: send email Telefono: +49 8955279080 Fax: +49 89552790879	DE (MUNCHEN BAYERN)	participant	1˙390˙134.00
4	SUPRAPOLIX BV  Organization address address: HORSTEN 1 city: EINDHOVEN postcode: 5612 AX contact info Titolo: Dr. Nome: Anton Cognome: Bosman Email: send email Telefono: +31 402472690	NL (EINDHOVEN)	participant	763˙800.00
5	APPLETREE CI GROUP AG  Organization address address: RUDOLF DIESEL STRASSE 3 city: WINTERTHUR postcode: 8404 contact info Titolo: Mr. Nome: Rubén Cognome: Ibáñez Email: send email Telefono: +41 522090640 Fax: +41 522090650	CH (WINTERTHUR)	participant	314˙292.00
6	MEDICUT STENT TECHNOLOGY GMBH  Organization address address: WILHELM BECKER STRASSE 11A city: PFORZHEIM postcode: 75179 contact info Titolo: Mr. Nome: Christian Cognome: Herzog Email: send email Telefono: +49 7231280100	DE (PFORZHEIM)	participant	292˙190.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'In situ tissue engineering using a biodegradable synthetic scaffold that recruits endogenous cells from the bloodstream is emerging as a promising technology to create living heart valves inside the human body having the potential to last a life-time: one valve for life. Compared to classical tissue engineered heart valves this new technology demonstrates off-the-shelf availability at substantially reduced cost. The current proposal aims to further develop the synthetic biomaterials needed for the in situ tissue engineering of heart valves, to process these materials into a functional heart valve scaffold, and to perform all the necessary pre-clinical experiments to enable first-in-man clinical application. A novel approach to the biodegradable scaffold will be developed, that combines a relatively slowly degrading (months) elastomeric material with a fast degrading (weeks) bioactive hydrogel material. These materials will be processed into a fibrous heart valve scaffold by means of electrospinning. The elastomeric material ensure long term functionality of the valve while supporting in-vivo mature tissue formation, while the fast eroding hydrogel material controls the early inflammatory response and creates the necessary void space between the elastomeric fibers. A minimally invasive, transapical, implantation technique will be used for the placement of the heart valve scaffold at the aortic position, following our recent results. For this purpose, tailor-made stents will be developed.'