BIO-POLYTEC

Enhanced Process Monitoring and Control Technology to Accelerate Development of Bioresorbable Polymeric Medical Devices

Coordinatore	INSTITUTE OF TECHNOLOGY SLIGO - ITS    more  Organization address address: BALLINODE - ASH LANE city: SLIGO contact info Titolo: Dr. Nome: Marion Cognome: Mcafee Email: send email Telefono: +353 861272231
Nazionalità Coordinatore	Ireland [IE]
Totale costo	1˙015˙391 €
EC contributo	787˙595 €
Programma	FP7-SME Specific Programme "Capacities": Research for the benefit of SMEs
Code Call	FP7-SME-2013
Funding Scheme	BSG-SME
Anno di inizio	2013
Periodo (anno-mese-giorno)	2013-12-01   -   2015-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTITUTE OF TECHNOLOGY SLIGO - ITS  Organization address address: BALLINODE - ASH LANE city: SLIGO contact info Titolo: Dr. Nome: Marion Cognome: Mcafee Email: send email Telefono: +353 861272231	IE (SLIGO)	coordinator	44˙608.80
2	FOS FASEROPTISCHE SYSTEME MESSTECHNIK GMBH  Organization address address: RUTGERSSTRASSE 40 city: SCHACHT AUDORF postcode: 24790 contact info Titolo: Dr. Nome: Erhard Cognome: Giese Email: send email Telefono: +49 43319065	DE (SCHACHT AUDORF)	participant	349˙001.25
3	SCAFFDEX OY  Organization address address: KALKUNKATU 21 B 21 B city: TAMPERE postcode: 33330 contact info Titolo: Ms Nome: Tuija Cognome: Annala Email: send email Telefono: +358 405053351	FI (TAMPERE)	participant	171˙349.50
4	INNOVATIVE POLYMER COMPOUNDS LIMITED  Organization address address: LOWER LEESON STREET 42 NCC HOUSE city: DUBLIN postcode: 2 contact info Titolo: Mr. Nome: Joe Cognome: Molloy Email: send email Telefono: 353579000000	IE (DUBLIN)	participant	156˙199.75
5	PLASMA BIOTAL LIMITED  Organization address address: MEVERILL ROAD - INDUSTRIAL ESTATE UNIT 5 UNIT 5 city: TIDESWELL postcode: SK17 8PY contact info Titolo: Mr. Nome: Paul Cognome: Steverson Email: send email Telefono: +44 1298872348	UK (TIDESWELL)	participant	44˙743.45
6	TTY-SAATIO  Organization address address: Korkeakoulunkatu 10 city: TAMPERE postcode: 33720 contact info Titolo: Prof. Nome: Minna Cognome: Kellomäki Email: send email Telefono: +358 405053351	FI (TAMPERE)	participant	7˙504.00
7	QUEEN'S UNIVERSITY BELFAST  Organization address address: University Road city: BELFAST postcode: BT7 1NN contact info Titolo: Prof. Nome: Fraser Cognome: Buchanan Email: send email Telefono: +44 289660974130	UK (BELFAST)	participant	7˙499.02
8	PURAC BIOCHEM BV  Organization address address: ARKELSEDIJK 46 46 city: GORINCHEM postcode: 4206AC contact info Titolo: Dr. Nome: Marc-Anton Cognome: Kruft Email: send email Telefono: +31 183 695 652	NL (GORINCHEM)	participant	6˙690.00

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 Obiettivo del progetto (Objective)

'The manufacture of bioresorbable medical devices for temporary implantation inside the human body is growing into a high-value industry with many benefits over traditional devices. Bioresorbable devices do not need a removal operation, reducing patient trauma and significant healthcare costs. Due to the ability to add antibacterial or antibiotic drugs and to control the release rate at the implant site, such devices can reduce the number of post-operative complications and open up possibilities for new therapies. However, development times for new devices can be lengthy and extremely expensive. Bioresorbable materials have a high cost and are difficult to process, resulting in high scrap rates. The addition of fillers such as bioactive particles further complicate the manufacture. In Bio-PolyTec, sensor technology - centering on optical spectroscopic techniques - will be developed for in-process monitoring of the key quality measures of polymer degradation and additive dispersion. The availability of this information in real-time rather than after time-consuming and expensive laboratory testing represents a significant improvement in Quality Control for bioresorbable devices as well as enabling better process control. The influence of typical processing procedures on the degradation and mixing and hence subsequent bioresorption/release behaviour and mechanical properties will be fully investigated for the commercial products of the consortium SMEs to optimise their processes to achieve specific and consistent product requirements. In particular the processing of Polylactic Acid (PLA) and dispersion of bioactive Calcium Phosphate particles for orthopaedic implants will be investigated among other polymer/filler systems. The innovations in sensor technology will extend outside the consortium to enable other device manufacturers to reduce scrap rates and hence production costs for bioresorbable devices. The 'trial-and-error' guesswork is taken out of the process development stage for new products, significantly reducing the time and cost and stimulating activity in the market. Possible batch-to-batch variation will be eliminated, avoiding adverse behaviour of the products after implantation in a patient.'