MEXTIM

Measurement of temperature exposure and integration over time

Coordinatore	JOHN INNES CENTRE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	2˙499˙997 €
EC contributo	2˙499˙997 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2013-ADG
Funding Scheme	ERC-AG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-03-01   -   2019-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MITTUNIVERSITETET  Organization address address: HOLMGATAN 10 city: SUNDSVALL postcode: 85170 contact info Titolo: Mrs. Nome: Eva Cognome: Karlsson Email: send email Telefono: +46 60 148727	SE (SUNDSVALL)	beneficiary	54˙000.00
2	LUNDS UNIVERSITET  Organization address address: Paradisgatan 5c city: LUND postcode: 22100 contact info Titolo: Mr. Nome: Peter Cognome: Stenild Matthesen Email: send email Telefono: +4646222 77 97	SE (LUND)	beneficiary	42˙000.00
3	JOHN INNES CENTRE  Organization address address: "Norwich Research Park, Colney" city: NORWICH postcode: NR4 7UH contact info Titolo: Dr. Nome: Mary Cognome: Anderson Email: send email Telefono: +44 1603 450244 Fax: +44 1603 450045	UK (NORWICH)	hostInstitution	2˙403˙997.00
4	JOHN INNES CENTRE  Organization address address: "Norwich Research Park, Colney" city: NORWICH postcode: NR4 7UH contact info Titolo: Prof. Nome: Caroline Cognome: Dean Email: send email Telefono: +44 1603 450526 Fax: +44 1603 450045	UK (NORWICH)	hostInstitution	2˙403˙997.00

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 Obiettivo del progetto (Objective)

'All organisms have to cope with changing temperature and various mechanisms have evolved to protect cellular processes against thermal stresses. Many organisms also use temperature signals to align behaviour and development with certain seasons. How specific temperature cues are extracted from fluctuating temperature levels is unknown but it implies the existence of mechanisms that enable long-term monitoring and integration of the enormously variable temperature levels found in nature. We therefore intend to discover how variable temperature levels are measured and integrated over long timescales in order to provide information used in biological timing. Plants provide an excellent system in which to investigate such thermo-sensory mechanisms. We will exploit our knowledge of the multiple regulatory pathways determining quantitative expression of the plant developmental repressor FLOWERING LOCUS C (FLC). These pathways, which are all independently influenced by temperature, converge to regulate FLC via aspects of a co-transcriptional mechanism involving antisense transcripts and different chromatin pathways. This understanding provides the system to define the primary temperature steps (thermo-sensors) that directly regulate FLC and explore how they combine to record complex temperature profiles. Our hypothesis is that different thermo-sensors monitor distinct aspects of the long-term temperature profile. Their outputs would be integrated via accumulation of chromatin modifications at FLC with feedback and interconnection between the pathways providing reinforcement systems to record previous exposure. Modulation of this mechanism would then provide the basis for adaptation to different climates. Knowledge emerging from this study will provide important concepts in understanding how organisms interact with their environment.'