BEATING HEART

Beating Heart

Coordinatore	UNIVERSITA DEGLI STUDI DI VERONA    more  Organization address address: VIA DELL ARTIGLIERE 8 city: VERONA postcode: 37129 contact info Titolo: Dr. Nome: Manuela Cognome: Calderara Email: send email Telefono: +39 0458124287 Fax: +39 0458027276
Nazionalità Coordinatore	Italy [IT]
Totale costo	182˙996 €
EC contributo	182˙996 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IOF
Funding Scheme	MC-IOF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-09-01   -   2016-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI VERONA  Organization address address: VIA DELL ARTIGLIERE 8 city: VERONA postcode: 37129 contact info Titolo: Dr. Nome: Manuela Cognome: Calderara Email: send email Telefono: +39 0458124287 Fax: +39 0458027276	IT (VERONA)	coordinator	182˙996.40

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 Obiettivo del progetto (Objective)

'Intravital microscopy (IVM) methods are enjoying an ever broader acceptance as they can be used to gain insight into cell biology in vivo. Unfortunately, most set-ups use window chambers (e.g. cancer) or isolated organs, all highly artificial model systems which are often not compatible with survival imaging. Because of these caveats, imaging in orthotopic locations is always preferable and can theoretically be achieved via motion compensation and tissue stabilization techniques. Recently, different approaches have been proposed including the use of suctioning devices for lung imaging. Unfortunately these approaches are not very effective in achieving stabilization. Moreover many of them induce severe damage to the myocardium. In this proposal we intend to develop a in-vivo real-time intravital microscopy imaging system for imaging moving organs (specifically the beating heart) at the sub-cellular resolution level, capable of compensating all motion artifacts inevitably present in in-vivo models. Our approach will use a combination of rigid motion stabilization through the design of novel stabilizers and sophisticated algorithms for acquisition during advanced cardiopulmonary gating. This system will allow for the first time to study in vivo the biology and physiology in the beating heart. This is at present a totally unexplored field due to the current lack of availability of any imaging technique. Results will be potentially exciting and innovative and will open a new paradigm in the understanding of the physiological properties of the heart and immune system responses.'