VTANORREGMOTCONTROL

VTA-specific noradrenergic regulation of motivational control

Coordinatore	INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK    more  Organization address address: SMETNA 12 city: KRAKOW postcode: 31-343 contact info Titolo: Prof. Nome: Ryszard Cognome: Przewlocki Email: send email Telefono: +4812 66 23 218 Fax: +4812 637 45 00
Nazionalità Coordinatore	Poland [PL]
Totale costo	140˙863 €
EC contributo	140˙863 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IIF
Funding Scheme	MC-IIF
Anno di inizio	2015
Periodo (anno-mese-giorno)	2015-02-01   -   2017-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	INSTYTUT FARMAKOLOGII POLSKIEJ AKADEMII NAUK  Organization address address: SMETNA 12 city: KRAKOW postcode: 31-343 contact info Titolo: Prof. Nome: Ryszard Cognome: Przewlocki Email: send email Telefono: +4812 66 23 218 Fax: +4812 637 45 00	PL (KRAKOW)	coordinator	140˙863.80

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 Obiettivo del progetto (Objective)

'Motivational control is crucial for adaptive behaviors. Conversely, disruption of motivational control leads to maladaptive behaviors and is one of the core symptoms of addiction. Noradrenaline (NA) system, encompassing NA neurons in locus coeruleus and nucleus tractus solitiarius is well positioned to regulate motivational control; however its exact contribution is not fully understood. Here we aim to evaluate the role of NA system activity in the ventral tegmental area (VTA) in motivational control in both opiate-naive and opiate-exposed mice. Using behavioral model of motivational control in combination with real-time, dynamic optical stimulation of NA neurons terminals in the VTA we plan to provide unprecedented data on NA mechanisms of motivational control and identify specific brain locus within the NA system responsible for specific type of motivational control. In addition, proposed project aims at transfering optogenetics 'know how' to the host Institution.'