PROTEIN-BIOFILM

Characterization of protein-dependent biofilms by Staphylococcus aureus

Coordinatore	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS    more  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Prof. Nome: Iñigo Cognome: Lasa Email: send email Telefono: 0034 948168007 Fax: 0034 948232191
Nazionalità Coordinatore	Spain [ES]
Totale costo	45˙000 €
EC contributo	45˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2007-2-2-ERG
Funding Scheme	MC-ERG
Anno di inizio	2007
Periodo (anno-mese-giorno)	2007-09-03   -   2010-09-02

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS  Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 contact info Titolo: Prof. Nome: Iñigo Cognome: Lasa Email: send email Telefono: 0034 948168007 Fax: 0034 948232191	ES (MADRID)	coordinator	0.00

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 Obiettivo del progetto (Objective)

'Nosocomial staphylococcal foreign-body infections related to biofilm formation are important problem in modern medicine and S. aureus has become one of the most important bacteria responsible for these chronic infections. The formation of adherent, multilayered bacterial biofilms is the most important factor in the pathogenesis of these infections, which regularly fail to respond to appropriate antimicrobial therapy. Given the impressive array of surface proteins expressed by S. aureus, it seems reasonable that some of them might be involved in biofilm development either in cooperation or independently of PIA/PNAG. Increasing number of evidences suggest the existence of protein dependent biofilm development on clinical isolates of S. aureus. The general objectives of my research proposal are to identify and characterize proteins involved in biofilm formation. The identification of novel biofilm therapeutic and preventive targets would aid in the development of new and more effective treatments for combating staphylococcal proteinaceous-building biofilm associated infections.'

Introduzione (Teaser)

European research is tackling the source of most outbreaks of hospital infections, Staphylococcus aureus (S. aureus). Attacking the bacterium's anti-microbial defence, the biofilm, the microbe should be easier to control.