BLOODY SIGNALS

Multidimensional analysis of signaling during normal hematopoietic differentiation and stress-induced regeneration

Coordinatore	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.    more  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Martina Cognome: Enderlein Email: send email Telefono: +49 761 5108 341 Fax: +49 761 5108 220
Nazionalità Coordinatore	Germany [DE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2015
Periodo (anno-mese-giorno)	2015-03-01   -   2019-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Ms. Nome: Martina Cognome: Enderlein Email: send email Telefono: +49 761 5108 341 Fax: +49 761 5108 220	DE (MUENCHEN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'Hematopoieic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into cells of all hematopoietic lineages. During steady-state, HSCs are mostly quiescent and responsible for normal hematopoietic differentiation. In cases of stress such as infection or injury, HSCs need to be activated and repair the hematopoeitic system in a regenerative response that involves synchronous and hierarchical replacement of the hematopoietic lineages. Multiple signaling pathways constantly specify a complex network of stimuli that HSCs need to decode and act on. Rapid recovery after injury is crucial for patients receiving myeloablative treatments, or suffering from a hematologic malignancy. It is therefore important to understand how signaling pathways control HSC responses during normal hematopoietic differentiation and stress induced regeneration. Our goal is to use zebrafish genetics and genome-wide techniques to understand how signaling pathways synergize and integrate with the internal hematopoietic program and control normal hematopoietic differentiation and stress-induced regeneration. Ultimately our approach may reveal new players of hematopoietic regeneration that can be exploited therapeutically.'