IRESOLUTION

The role of Western lifestyle factors in smoke-induced inflammation in chronic obstructive pulmonary disease

 Coordinatore ACADEMISCH ZIEKENHUIS LEIDEN 

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Prof.
Nome: Pieter Sicco
Cognome: Hiemstra
Email: send email
Telefono: +31 71 5263848

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 175˙974 €
 EC contributo 175˙974 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-09-01   -   2016-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Prof.
Nome: Pieter Sicco
Cognome: Hiemstra
Email: send email
Telefono: +31 71 5263848

NL (LEIDEN) coordinator 175˙974.60

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

anti    lifestyle    mechanisms    mediators    pro    sunlight    inflammatory    resolution    copd    resolving    inflammation    chronic    western    disease    diseases   

 Obiettivo del progetto (Objective)

'Over the past century a substantial increase in the incidence of chronic inflammatory diseases has been observed in industrialized countries. This unexpected rise in diseases such as chronic obstructive pulmonary disease (COPD), asthma and inflammatory bowel disease has led to concern about how Western lifestyle may negatively influence our (anti-)inflammatory defense mechanisms. Inflammation is a process that needs to be actively terminated with help of anti-inflammatory and pro-resolving mediators. Several of these mediators are derived from molecules in our environment such as sunlight and nutrition. Accumulating evidence now suggests that Western lifestyle results in a lack of sufficient exposure to sunlight and insufficient intake of particular nutrients due to our diet, resulting in a reduced availability of essential anti-inflammatory and pro-resolving mediators in the body. The work described in this proposal aims to map the role of anti-inflammatory and pro-resolving mediators in smoke-induced inflammation in COPD. The outcomes of this study are expected to contribute to a better understanding of the resolution phase of inflammation and result in the identification of novel therapeutic targets that are applicable for COPD and possibly more inflammatory diseases. Obtaining new insights in the mechanisms underlying resolution of inflammation is of utmost importance to provide a foundation to curb the rise in inflammatory diseases.'

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