CENTRIOLE_LENGTH

Molecular basis of centriole length control

Coordinatore	PAUL SCHERRER INSTITUT    more  Organization address address: Villigen city: VILLIGEN PSI postcode: 5232 contact info Titolo: Mrs. Nome: Irene Cognome: Walthert Email: send email Telefono: +41 56 310 2664
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	199˙317 €
EC contributo	199˙317 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IEF
Funding Scheme	MC-IEF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-03-01   -   2016-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	PAUL SCHERRER INSTITUT  Organization address address: Villigen city: VILLIGEN PSI postcode: 5232 contact info Titolo: Mrs. Nome: Irene Cognome: Walthert Email: send email Telefono: +41 56 310 2664	CH (VILLIGEN PSI)	coordinator	199˙317.60

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 Obiettivo del progetto (Objective)

'Centrioles play a key role in the assembly of the centrosome, the major microtubule organizing center, and are crucial for the formation of cilia and flagella. Significant progress has been made toward understanding centriole biogenesis, but the mechanisms that determine centriole length and prevent centrioles from forming cilia or flagella remain unknown. CP110, Cep97, Cep120, CPAP, SPICE1 and centrobin have been identified as key players in these fundamental biological processes. The overarching aim of this research proposal is to understand how these proteins cooperate in order to control centriole length. The following unresolved questions will be addressed:

1) What is the molecular mechanism of the interactions between centriolar proteins that play a key role in controlling centriole length and cilia formation?

2) How do the proteins involved in centriole length control interact with tubulin and microtubules?

3) What is the functional importance of interactions of key proteins in controlling centriole length and cilia formation?

A multidisciplinary approach encompassing state-of-the-art bioinformatics, biochemical, biophysical, and structural and cell biology methods will be used to tackle these open questions. The results will significantly contribute to our understanding of centriole and cilia biogenesis. Ultimately, the proposed research will help to understand how misregulation of these processes leads to human diseases such as cancer, polycystic kidney disease, microcephaly, dwarfism, and primary ciliary dyskinesia.'