SUGARYBONE
The Role of Protein N-Glycosylation in Bone and Energy Homeostasis
| Coordinatore | GENOME RESEARCH LIMITED
Organization address
address: THE GIBBS BUILDING, EUSTON ROAD 215 contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 221˙606 € |
| EC contributo | 221˙606 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2013-IEF |
| Funding Scheme | MC-IEF |
| Anno di inizio | 2014 |
| Periodo (anno-mese-giorno) | 2014-05-01 - 2016-04-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
GENOME RESEARCH LIMITED
Organization address
address: THE GIBBS BUILDING, EUSTON ROAD 215 contact info |
UK (LONDON) | coordinator | 221˙606.40 |
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Obiettivo del progetto (Objective)
'Osteoporotic bone loss due to aging or disease is a major health issue that affects hundreds of millions of people worldwide and costs tens of billions of euros each year. Since current osteoporosis medication only reduces fracture risk by 25-50%, there is an urgent need to define new pathways that control bone remodelling and strength in order to identify new therapeutic targets. Via the ‘Mouse Genetics Project’ consortium, we identified a mutation in one of the enzymes involved in the N-linked protein glycosylation pathway that leads to profound osteoporosis and obesity in mice; this observation accorded with the outcome of comparable human pathologies (congenital disorders of glycosylation). Though bone contains a large amount of glycoproteins, the importance of protein N-glycosylation to skeletal homeostasis remains to be characterised. This project aims (1) to identify the role of protein N-glycosylation in bone homeostasis, (2) to assess mechanistically how bone cell functioning is regulated by this process, and (3) to characterise the metabolic abnormalities associated with defects in N-glycosylation and to address its linkage to bone. We hypothesise that defective N-glycosylation impairs bone formation by osteoblasts, leading to the observed osteoporosis, and, likely, reduced bone-derived osteocalcin levels, which will in turn result in hampered insulin release and insulin resistance, with the observed obesity as a consequence. By combining the applicant’s and host’s skills in mouse genetics, skeletal phenotyping and high-throughput techniques, with the expertise in energy homeostasis, mouse embryonic stem cell technologies and (glyco)proteomics at the Wellcome Trust Sanger Institute, we are confident to gain insight in a process that most possibly regulates osteoblast functioning and bone matrix production; this knowledge will contribute to the development of novel, urgently warranted anabolic medication to treat osteoporosis.'