MISTRAL

MITOCHONDRIAL STEROIDOGENESIS in the ADRENAL

 Coordinatore THE UNIVERSITY OF BIRMINGHAM 

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Mr.
Nome: Xavier
Cognome: Rodde
Email: send email
Telefono: 441214000000
Fax: 441214000000

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 231˙283 €
 EC contributo 231˙283 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-04-14   -   2016-04-13

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Mr.
Nome: Xavier
Cognome: Rodde
Email: send email
Telefono: 441214000000
Fax: 441214000000

UK (BIRMINGHAM) coordinator 231˙283.20

Mappa

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 Word cloud

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adult    mechanisms    steroidogenesis    questions    stress    enzymes    zebrafish    cofactor    function    models    regulation    regulatory    pathways    vivo    insights    steroid    disrupted    hormones    fundamental   

 Obiettivo del progetto (Objective)

'Steroid hormones to control sex development, metabolism, stress response, blood pressure and body composition. Steroid hormones synthesis and action is conserved across species. The importance of cofactors in the function of steroidogenic enzymes has become apparent during recent years. Data from in vitro research suggests important regulatory capacity of co-factors significantly influencing total steroid hormone production. However, the significance of these mechanisms in vivo remains elusive. Our central hypothesis is that cofactor regulation of mitochondrial cytochrome P450 enzymes is a key regulatory mechanism of steroidogenesis. Thus, following a novel approach to address these unanswered research questions, this project will address these questions in zebrafish. This will have the advantage that consequences of disrupted steroidogenesis can be easily studied in embryos and in adult animals. Two zebrafish models will be used to dissect the first and rate limiting step of steroidogenesis by disrupting the enzymatic function as well as the cofactor function. Comparing these two models will provide novel mechanistic insights into the regulation of the crucial step of steroidogenesis. Since this can have vital consequences on the developing and adult organisms, we will conduct in vivo studies analysing the response of regulatory pathways to differentially disrupted steroidogenesis. In addition, we will study the impact of cofactor modifications on steroidogenesis to explore novel mechanisms regulating key parts of steroidogenesis. Thus this project will lead to a better understanding of the fundamental mechanisms underlying the regulation of steroidogenesis. This will provide novel insights into physiological processes and fundamental pathways during development and adult life. Finally, the identification of new interactions is highly likely, which can be targeted for development of novel antihypertensive drugs and substances modulating stress response.'

Altri progetti dello stesso programma (FP7-PEOPLE)

PTSD AND SMOKING (2009)

Posttraumatic Stress Disorder and Smoking Cessation

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LANGEVO (2011)

Cultural and Biological Bases of Language Evolution

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RASMIM (2013)

Reactivity of Aluminium Sulphate Minerals In Mine wastes (RASMIM)

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