NONCOSENSE

Identifying long non-coding RNAs with a role in Oncogenic-Induced Senescence

 Coordinatore KOBENHAVNS UNIVERSITET 

 Organization address postcode: 1017

contact info
Titolo: Mrs.
Nome: Tine
Cognome: Mathiesen
Email: send email
Telefono: +45 35320478

 Nazionalità Coordinatore Denmark [DK]
 Totale costo 221˙154 €
 EC contributo 221˙154 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-03-01   -   2016-02-29

 Partecipanti

# participant  country  role  EC contrib. [€] 
1 KOBENHAVNS UNIVERSITET DK coordinator 221˙154.60

Mappa

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 Word cloud

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cellular    majority    genome    host    roles    lncrnas    biology    cancer    ncrna    rna    senescence    recently    coding    demonstrated    cell   

 Obiettivo del progetto (Objective)

'The sequencing of the human genome has revealed that protein-coding genes correspond only to approximately 2% of the genome. Despite of this, the vast majority of the mammalian genome is actively transcribed. Thus, it is intriguing what this non-coding RNA (ncRNA), which was previously considered as transcriptional “noise”, is doing in the cell. New high-throughput technologies and novel RNA methodologies have demonstrated that there are different classes of ncRNA and that they may have pivotal roles in cellular processes. The project proposed here is focused on understanding the role of a recently discovered class of ncRNAs, long non-coding RNAs (lncRNAs). Although this is largely an unexplored field and the majority of lncRNAs remain to be characterized, several lncRNAs have been demonstrated to have important roles in processes such as proliferation or differentiation and hereby inferred roles in diseases including cancer. This highlights the importance of elucidating the roles of lncRNAs in cellular physiology and pathology. In the present project, my aim is identifying lncRNAs deregulated and functionally important in senescence, the process in which cells enter an irreversible growth arrest following oncogenic insults or telomere erosion. Towards this, I will use broad set of cell biology, biochemistry and genetics approaches and I will combine my previous expertise in RNA biology with new knowledge and cutting edge techniques in the ncRNA field that I will acquire in the host group. I will take advantage of collaborations from several European networks as well as from a Marie Curie Initial Training Network that the host PI was recently awarded. This project will help not only to uncover unknown functions of lncRNAs in cellular regulation but also, since oncogene-induced senescence is considered a mechanism to protect the cell against cancer, it holds the potential to discover lncRNAs that can be used as diagnosis markers and therapeutic interventions.'

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Implications of the mesopelagic Remineralization for the OceaN Iron Cycle

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DNA RECOGNITION (2010)

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REPLACOMB (2012)

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